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Nucleolar Protein 14 (NOL14)

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RES4-25; C4orf9; NOP14; Nucleolar complex protein 14

Nucleolar Protein 14 (NOL14)
CCC P049
HGNC 16821
MGI 1922666
RGD 1305605
UniProt P78316
NOP14 plays a role in the processing of the pre-18S rRNA and small ribosomal subunit assembly. The central domain (amino acids 170 to 469) of yeast Nop14 interacted with Emg1 and that mouse Emg1 and human NOP14 interacted. Emg1 localized to both nuclear and cytoplasmic fractions in the presence of Nop14 but to the cytoplasmic fraction only in Nop14-depleted cells. Pulse-chase labeling of ribosomal RNA transcript processing in Nop14-depleted yeast showed a processing defect characterized by absence of the 18S rRNA species and its 20S precursor and normal levels of 25S rRNA, similar to the phenotype observed in Emg1 conditional mutant yeast. Sucrose density gradient profiling of cellular ribosomes and polysome runoff strains found significantly reduced levels of 40S subunits compared to 60S.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Protein 14 (NOL14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Protein 14 (NOL14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Protein 14 (NOL14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Protein 14 (NOL14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Protein 14 (NOL14) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Protein 14 (NOL14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Protein 14 (NOL14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Protein 14 (NOL14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Protein 14 (NOL14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Protein 14 (NOL14) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Protein 14 (NOL14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Protein 14 (NOL14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Protein 14 (NOL14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Protein 14 (NOL14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Protein 14 (NOL14) ELISA Kit Customized Service Offer
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