SEC22 Vesicle Trafficking Protein Homolog C (SEC22C)

SNAP receptors, or SNAREs, determine the specificity of the docking and fusion of vesicles to the correct target membranes. The S. cerevisiae Sec22, Bet1, and Bos1 SNAREs are interacting proteins that play a role in endoplasmic reticulum (ER)-Golgi transport.Northern blot analysis revealed that SEC22C is expressed ubiquitously as 1- and 5-kb mRNAs. The predicted 250-amino acid SEC22C protein shares 36% and 19% sequence identity with rat SEC22A and mouse Sec22b, respectively. SEC22C accumulated primarily at the ER.

As with Sec22b, overexpression of recombinant SEC22C protein disrupted the localization of SNAREs involved in ER-Golgi transport, indicating that SEC22C protein plays a role in ER-Golgi protein trafficking.