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Aortic Preferentially Expressed Gene 1 (APEG1)

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SPEG; SPEGalpha; SPEGbeta; BPEG; Striated muscle preferentially expressed protein kinase

Aortic Preferentially Expressed Gene 1 (APEG1)
CCC P035
HGNC 16901
MGI 109282
PubMed 16545539
UniProt Q15772
The cDNA of rat APEG-1 contained an open reading frame encoding 113 amino acids, which would predict a basic protein of 12.7 kDa. The amino acid sequence of rat APEG-1 was highly conserved among human and mouse homologues (97 and 98%, respectively). By in situ hybridization, APEG-1 mRNA was expressed in rat ASMC. Although APEG-1 was expressed highly in differentiated ASMC in vivo, its expression was quickly down-regulated and disappeared in dedifferentiated ASMC in culture. In vivo, APEG-1 mRNA levels decreased by more than 80% in response to vascular injury as ASMC changed from a quiescent to a proliferative phenotype. Taken together, these data indicate that APEG-1 is a novel marker for differentiated ASMC and may have a role in regulating growth and differentiation of this cell type.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aortic Preferentially Expressed Gene 1 (APEG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aortic Preferentially Expressed Gene 1 (APEG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aortic Preferentially Expressed Gene 1 (APEG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aortic Preferentially Expressed Gene 1 (APEG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aortic Preferentially Expressed Gene 1 (APEG1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aortic Preferentially Expressed Gene 1 (APEG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aortic Preferentially Expressed Gene 1 (APEG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aortic Preferentially Expressed Gene 1 (APEG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aortic Preferentially Expressed Gene 1 (APEG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aortic Preferentially Expressed Gene 1 (APEG1) ELISA Kit Customized Service Offer
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  8. "X-ray structure of engineered human aortic preferentially expressed protein-1 (APEG-1)."BMC Struct. Biol. 5:21-21(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  10. "SPEG interacts with myotubularin, and its deficiency causes centronuclear myopathy with dilated cardiomyopathy."Am. J. Hum. Genet. 95:218-226(2014) [PubMed] [Europe PMC] [Abstract]