≡

SLU7 Splicing Factor Homolog (SLU7)

[Edit]

9G8; Zinc Knuckle Motif Containing; Pre-mRNA-splicing factor SLU7

SLU7 Splicing Factor Homolog (SLU7)
CCC P029
HGNC 16939
MGI 2385598
PubMed 8756413
RGD 631432
UniProt O95391
Wiki SLU7
Splicing factors for step 2, such as PRP18 and SLU7, bring near and distant 3-prime splice sites into the active site of the spliceosome.The deduced 586-amino acid protein is 204 amino acids longer than yeast Slu7 and is 41% identical to the worm and Arabidopsis proteins.
SLU7 contains a zinc knuckle, a motif found in several splicing factors. Western blot analysis showed expression of a 70-kD nuclear protein that associates with the spliceosome relatively late in the assembly process. The association of SLU7 with the spliceosome is coupled to the catalysis of step 1. Depletion of SLU7 resulted in the accumulation of novel intermediate C-type spliceosomal complexes that were blocked before step 2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SLU7 Splicing Factor Homolog (SLU7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SLU7 Splicing Factor Homolog (SLU7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SLU7 Splicing Factor Homolog (SLU7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SLU7 Splicing Factor Homolog (SLU7) CLIA Kit Customized Service Offer
n/a ELISA Kit for SLU7 Splicing Factor Homolog (SLU7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SLU7 Splicing Factor Homolog (SLU7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SLU7 Splicing Factor Homolog (SLU7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SLU7 Splicing Factor Homolog (SLU7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SLU7 Splicing Factor Homolog (SLU7) CLIA Kit Customized Service Offer
n/a ELISA Kit for SLU7 Splicing Factor Homolog (SLU7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SLU7 Splicing Factor Homolog (SLU7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SLU7 Splicing Factor Homolog (SLU7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SLU7 Splicing Factor Homolog (SLU7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SLU7 Splicing Factor Homolog (SLU7) CLIA Kit Customized Service Offer
n/a ELISA Kit for SLU7 Splicing Factor Homolog (SLU7) ELISA Kit Customized Service Offer
  1. "Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing."Genes Dev. 13:841-850(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The RNA splicing factor hSlu7 is required for correct 3' splice-site choice."Nature 402:207-210(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The birth of an alternatively spliced exon: 3' splice-site selection in Alu exons."Science 300:1288-1291(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus."Mol. Biol. Cell 15:3782-3795(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing."J. Cell Sci. 118:1151-1159(2005) [PubMed] [Europe PMC] [Abstract]
  8. ErratumJ. Cell Sci. 118:1331-1331(2005)
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7."Biochim. Biophys. Acta 1813:1045-1049(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]