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Mortality Factor 4 Like Protein 1 (MORF4L1)

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MRG15; MORFRG15; Eaf3; MEAF3; MORF-Related Gene On Chromosome 15; Esa1p-Associated Factor 3 Homolog; Transcription factor-like protein MRG15

Mortality Factor 4 Like Protein 1 (MORF4L1)
CCC P021
HGNC 16989
MGI 1096551
PubMed 24451372
UniProt Q9UBU8
Wiki MORF4L1
The protein contains an N-terminal chromodomain, a bipartite nuclear localization signal, a helix-loop-helix domain, a region showing similarity to Drosophila Msl3, and a C-terminal leucine zipper motif. It also has a putative cAMP phosphorylation site, a protein kinase C phosphorylation site, and a tyrosine phosphorylation site. Northern blot analysis of multiple tissues revealed ubiquitous expression of a 1.8-kb transcript and, at lower levels, a 1.4-kb transcript. Zoo blot analysis revealed conservation of MRG15 from chicken to human. Transient transfection of HeLa cells with fluorescence-tagged MRG15 resulted in nuclear localization.Overexpression of MRG15 in HeLa cells ultimately caused abnormal nuclear morphology and cell death.expression of MRG15 declined slightly in normal senescent fibroblasts and increased following serum stimulation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mortality Factor 4 Like Protein 1 (MORF4L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mortality Factor 4 Like Protein 1 (MORF4L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mortality Factor 4 Like Protein 1 (MORF4L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mortality Factor 4 Like Protein 1 (MORF4L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mortality Factor 4 Like Protein 1 (MORF4L1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mortality Factor 4 Like Protein 1 (MORF4L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mortality Factor 4 Like Protein 1 (MORF4L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mortality Factor 4 Like Protein 1 (MORF4L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mortality Factor 4 Like Protein 1 (MORF4L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mortality Factor 4 Like Protein 1 (MORF4L1) ELISA Kit Customized Service Offer
  1. "Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes."Mol. Cell. Biol. 19:1479-1485(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex."J. Biol. Chem. 278:42733-42736(2003) [PubMed] [Europe PMC] [Abstract]
  9. "MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14."J. Biol. Chem. 276:39171-39178(2001) [PubMed] [Europe PMC] [Abstract]
  10. "MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation."J. Biol. Chem. 277:50860-50866(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and transducin-like enhancer of Split."Mol. Cell. Biol. 22:7868-7876(2002) [PubMed] [Europe PMC] [Abstract]
  12. "The highly conserved and multifunctional NuA4 HAT complex."Curr. Opin. Genet. Dev. 14:147-154(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans."Mol. Cell. Biol. 24:1884-1896(2004) [PubMed] [Europe PMC] [Abstract]
  14. "p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage."J. Cell. Physiol. 221:594-602(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  16. "MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks."J. Cell Sci. 123:1124-1130(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14."Protein Sci. 15:2423-2434(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain."Structure 14:151-158(2006) [PubMed] [Europe PMC] [Abstract]