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Transmembrane Emp24 Protein Transport Domain Containing Protein 10 (TMED10)

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TMP21; P24; 21 kDa transmembrane-trafficking protein; Transmembrane protein Tmp21; p24 family protein delta-1

Transmembrane Emp24 Protein Transport Domain Containing Protein 10 (TMED10)
CCC P018
HGNC 16998
MGI 1915831
PubMed 7596406
RGD 620970
UniProt P49755
Wiki TMED10
TMED10 is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. The deduced 219-amino acid type I intracellular transmembrane protein contains a signal sequence and is predicted to be located in the lumen of the endoplasmic reticulum. Northern blot analysis detected a 1.4-kb TMP21 transcript. Immunoblot analysis showed that the rat Tmp21 protein is expressed predominantly in the microsomal fraction of pancreatic acinar cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Emp24 Protein Transport Domain Containing Protein 10 (TMED10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Emp24 Protein Transport Domain Containing Protein 10 (TMED10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Emp24 Protein Transport Domain Containing Protein 10 (TMED10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Emp24 Protein Transport Domain Containing Protein 10 (TMED10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Emp24 Protein Transport Domain Containing Protein 10 (TMED10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Emp24 Protein Transport Domain Containing Protein 10 (TMED10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Emp24 Protein Transport Domain Containing Protein 10 (TMED10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Emp24 Protein Transport Domain Containing Protein 10 (TMED10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Emp24 Protein Transport Domain Containing Protein 10 (TMED10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Emp24 Protein Transport Domain Containing Protein 10 (TMED10) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Emp24 Protein Transport Domain Containing Protein 10 (TMED10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Emp24 Protein Transport Domain Containing Protein 10 (TMED10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Emp24 Protein Transport Domain Containing Protein 10 (TMED10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Emp24 Protein Transport Domain Containing Protein 10 (TMED10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Emp24 Protein Transport Domain Containing Protein 10 (TMED10) ELISA Kit Customized Service Offer
  1. "Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking."J. Biol. Chem. 271:17183-17189(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease." Nature 375:754-760(1995) [PubMed] [Europe PMC] [Abstract]
  3. "A comparative study of rat and human Tmp21 (p23) reveals the pseudogene-like features of human Tmp21-II."DNA Seq. 10:121-126(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  6. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
  9. "gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer."J. Cell Biol. 140:751-765(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors."Cell 96:495-506(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members."Mol. Biol. Cell 10:1939-1955(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Decoding of sorting signals by coatomer through a GTPase switch in the COPI coat complex."Cell 100:671-679(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Identification and characterization of novel isoforms of COP I subunits."J. Biochem. 128:793-801(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Coupled transport of p24 family members."J. Cell Sci. 113:2507-2516(2000) [PubMed] [Europe PMC] [Abstract]
  15. "Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23."EMBO J. 20:6751-6760(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway."J. Biol. Chem. 277:46504-46511(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins."Mol. Cell. Biol. 26:8011-8021(2006) [PubMed] [Europe PMC] [Abstract]
  19. "TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity."Nature 440:1208-1212(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism."Mol. Neurodegener. 2:4-4(2007) [PubMed] [Europe PMC] [Abstract]
  21. "The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi."Mol. Biol. Cell 19:1976-1990(2008) [PubMed] [Europe PMC] [Abstract]
  22. "GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi."Cell 139:352-365(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Arf GAP2 is positively regulated by coatomer and cargo."Cell. Signal. 21:1169-1179(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Selective export of human GPI-anchored proteins from the endoplasmic reticulum."J. Cell Sci. 123:1705-1715(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  26. "Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi."Biol. Cell 103:333-350(2011) [PubMed] [Europe PMC] [Abstract]
  27. "Proteinase-activated receptors, nucleotide P2Y receptors, and mu-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking."J. Neurochem. 117:71-81(2011) [PubMed] [Europe PMC] [Abstract]
  28. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]