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Cleavage And Polyadenylation Factor I (CLP1)

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HEAB; ATP/GTP Binding Protein; Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polyadenylation factor Clp1; Polynucleotide kinase Clp1; Pre-mRNA cleavage complex II protein Clp1

Cleavage And Polyadenylation Factor I (CLP1)
CCC P017
HGNC 16999
MGI 2138968
PubMed 18951025
RGD 1307679
UniProt Q92989
The deduced 425-amino acid protein is valine- and leucine-rich and contains a domain sharing similarity with the ATP/GTP-binding domain of ABC transporters. It also has a possible tyrosine kinase phosphorylation site. Northern blot analysis detected a major 2.0-kb transcript that was expressed ubiquitously, with highest expression in testis and skeletal muscle.
CLP1 interacted with CFIm and cleavage-polyadenylation specificity factor (CPSF), suggesting that it bridges these two 3-prime end processing factors within the cleavage complex.the physiologic role of CLP1 as the RNA kinase that phosphorylates the 5-prime end of the 3-prime exon during human tRNA splicing, allowing the subsequent ligation of both exon halves by an unknown tRNA ligase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cleavage And Polyadenylation Factor I (CLP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cleavage And Polyadenylation Factor I (CLP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cleavage And Polyadenylation Factor I (CLP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cleavage And Polyadenylation Factor I (CLP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cleavage And Polyadenylation Factor I (CLP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cleavage And Polyadenylation Factor I (CLP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cleavage And Polyadenylation Factor I (CLP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cleavage And Polyadenylation Factor I (CLP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cleavage And Polyadenylation Factor I (CLP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cleavage And Polyadenylation Factor I (CLP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cleavage And Polyadenylation Factor I (CLP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cleavage And Polyadenylation Factor I (CLP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cleavage And Polyadenylation Factor I (CLP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cleavage And Polyadenylation Factor I (CLP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cleavage And Polyadenylation Factor I (CLP1) ELISA Kit Customized Service Offer
  1. "AF10 is split by MLL and HEAB, a human homolog to a putative Caenorhabditis elegans ATP/GTP-binding protein in an invins(10;11)(p12;q23q12)."Blood 88:3535-3545(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors."EMBO J. 19:5895-5904(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation."Cell 117:311-321(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs."Nature 447:222-226(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Human RNA 5'-kinase (hClp1) can function as a tRNA splicing enzyme in vivo."RNA 14:1737-1745(2008) [PubMed] [Europe PMC] [Abstract]
  8. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function." Cell 157:636-650(2014) [PubMed] [Europe PMC] [Abstract]
  10. "CLP1 founder mutation links tRNA splicing and maturation to cerebellar development and neurodegeneration." Cell 157:651-663(2014) [PubMed] [Europe PMC] [Abstract]