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SNF8, ESCRT-II Complex Subunit Homolog (SNF8)

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EAP30; VPS22; Dot3; ELL-associated protein of 30 kDa; ESCRT-II complex subunit VPS22

SNF8, ESCRT-II Complex Subunit Homolog (SNF8)
CCC P012
HGNC 17028
MGI 1343161
PubMed 10419521
RGD 1310144
UniProt Q96H20
Wiki SNF8
SNF8, VPS25, and VPS36 form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. SNF8, VPS25, and VPS36 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL) .
Eap30 and Eap20 (VPS25) could be coimmunoprecipitated in the absence of Eap45 (VPS36), and that Eap20 and Eap45 could be coimmunoprecipitated in the absence of Eap30. However, little Eap30 was coimmunoprecipitated with Eap45 in the absence of Eap20. recombinant EAP30 could interact with recombinant ELL in vitro and derepress the inhibitory activity of ELL against RNA polymerase II.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SNF8, ESCRT-II Complex Subunit Homolog (SNF8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SNF8, ESCRT-II Complex Subunit Homolog (SNF8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SNF8, ESCRT-II Complex Subunit Homolog (SNF8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SNF8, ESCRT-II Complex Subunit Homolog (SNF8) CLIA Kit Customized Service Offer
n/a ELISA Kit for SNF8, ESCRT-II Complex Subunit Homolog (SNF8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SNF8, ESCRT-II Complex Subunit Homolog (SNF8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SNF8, ESCRT-II Complex Subunit Homolog (SNF8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SNF8, ESCRT-II Complex Subunit Homolog (SNF8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SNF8, ESCRT-II Complex Subunit Homolog (SNF8) CLIA Kit Customized Service Offer
n/a ELISA Kit for SNF8, ESCRT-II Complex Subunit Homolog (SNF8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SNF8, ESCRT-II Complex Subunit Homolog (SNF8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SNF8, ESCRT-II Complex Subunit Homolog (SNF8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SNF8, ESCRT-II Complex Subunit Homolog (SNF8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SNF8, ESCRT-II Complex Subunit Homolog (SNF8) CLIA Kit Customized Service Offer
n/a ELISA Kit for SNF8, ESCRT-II Complex Subunit Homolog (SNF8) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of the EAP30 subunit of the ELL complex that confers derepression of transcription by RNA polymerase II."J. Biol. Chem. 274:21981-21985(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The protein network of HIV budding."Cell 114:701-713(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins."Proc. Natl. Acad. Sci. U.S.A. 100:12414-12419(2003) [PubMed] [Europe PMC] [Abstract]
  5. ErratumProc. Natl. Acad. Sci. U.S.A. 100:152845-152845(2003)
  6. "RILP interacts with the VPS22 component of the ESCRT-II complex."Biochem. Biophys. Res. Commun. 347:1074-1079(2006) [PubMed] [Europe PMC] [Abstract]
  7. "RILP interacts with VPS22 and VPS36 of ESCRT-II and regulates their membrane recruitment."Biochem. Biophys. Res. Commun. 350:413-423(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Rapid identification of 14-3-3-binding proteins by protein microarray analysis."J. Neurosci. Methods 152:278-288(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release."J. Virol. 80:9465-9480(2006) [PubMed] [Europe PMC] [Abstract]
  10. "RILP is required for the proper morphology and function of late endosomes."J. Cell Sci. 120:3729-3737(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation."Traffic 8:1617-1629(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking."Exp. Cell Res. 314:801-813(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex."Dev. Cell 14:902-913(2008) [PubMed] [Europe PMC] [Abstract]