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SEC31 Homolog A (SEC31A)

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SEC31L1; ABP125; ABP130; SEC31-like protein 1

SEC31 Homolog A (SEC31A)
CCC P007
HGNC 17052
MGI 1916412
PubMed 10048485
RGD 620233
UniProt O94979
Wiki SEC31A
SEC31A is similar to yeast Sec31 protein. Yeast Sec31 protein is known to be a component of the COPII protein complex which is responsible for vesicle budding from endoplasmic reticulum (ER). This protein was found to colocalize with SEC13, one of the other components of COPII , in the subcellular structures corresponding to the vesicle transport function. An immunodepletion experiment confirmed that this protein is required for ER-Golgi transport. Alternative splicing results in multiple transcript variants encoding different isoforms. The deduced 1,218-amino acid protein shares 25.8% identity with yeast Sec31. It contains 5 WD40 or WD40-like repeats at its N terminus and a proline-rich region in its C-terminal half. Northern blot analysis detected a 4-kb transcript that was abundantly and ubiquitously expressed.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SEC31 Homolog A (SEC31A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SEC31 Homolog A (SEC31A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SEC31 Homolog A (SEC31A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SEC31 Homolog A (SEC31A) CLIA Kit Customized Service Offer
n/a ELISA Kit for SEC31 Homolog A (SEC31A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SEC31 Homolog A (SEC31A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SEC31 Homolog A (SEC31A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SEC31 Homolog A (SEC31A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SEC31 Homolog A (SEC31A) CLIA Kit Customized Service Offer
n/a ELISA Kit for SEC31 Homolog A (SEC31A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SEC31 Homolog A (SEC31A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SEC31 Homolog A (SEC31A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SEC31 Homolog A (SEC31A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SEC31 Homolog A (SEC31A) CLIA Kit Customized Service Offer
n/a ELISA Kit for SEC31 Homolog A (SEC31A) ELISA Kit Customized Service Offer
  1. "Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport."J. Biol. Chem. 275:13597-13604(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of the putative mammalian orthologue of Sec31P, a component of the COPII coat."J. Cell Sci. 112:4547-4556(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The Ca2+-binding protein ALG-2 is recruited to endoplasmic reticulum exit sites by Sec31A and stabilizes the localization of Sec31A."Mol. Biol. Cell 17:4876-4887(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor."Int. J. Cancer 118:1181-1186(2006) [PubMed] [Europe PMC] [Abstract]
  11. "ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner."Biochem. Biophys. Res. Commun. 353:756-763(2007) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Ubiquitin-dependent regulation of COPII coat size and function."Nature 482:495-500(2012) [PubMed] [Europe PMC] [Abstract]
  18. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]