Lengsin (LGSN)
[Edit]GLULD1; LGS; Lens Glutamine Synthase-Like; Glutamate-Ammonia Ligase(Glutamine Synthetase)Domain Containing 1; Lens Protein With Glutamine Synthetase Domain
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GLULD1 was among the most abundant cDNAs identified in adult lens, and EST database analysis showed that GLULD1 is among the most abundant noncrystallin mRNAs in human lens.GLULD1 homologs were restricted to vertebrate eye-bearing organisms. All orthologs contain a putative 14-3-3 protein-binding site, which is absent in GLUL.
GLULD1 transcripts were identified in human lens, total eye, and whole embryo ESTs, indicating preferential expression in the lens. Western blot analysis detected a 57-kD band in extracts from transparent but not cataractous lens. Hydrophobic surface probe bis-ANS bound to 6 sites on lengsin, supporting a possible role as a chaperone; however, no anti-aggregating effect of lengsin was found.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Lengsin (LGSN) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Lengsin (LGSN) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Lengsin (LGSN) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Lengsin (LGSN) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Lengsin (LGSN) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Lengsin (LGSN) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Lengsin (LGSN) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Lengsin (LGSN) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Lengsin (LGSN) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Lengsin (LGSN) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Lengsin (LGSN) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Lengsin (LGSN) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Lengsin (LGSN) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Lengsin (LGSN) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Lengsin (LGSN) | ELISA Kit Customized Service Offer |
- "Structural and functional properties of lengsin, a pseudo-glutamine synthetase in the transparent human lens."Biochem. Biophys. Res. Commun. 350:424-429(2006) [PubMed] [Europe PMC] [Abstract]
- "Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants."Mol. Vis. 8:171-184(2002) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]