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SEC63 Homolog (SEC63)

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SEC63L; ERdj2

SEC63 Homolog (SEC63)
CCC N986
HGNC 21082
MGI 2155302
PubMed 15133510
RGD 1304984
UniProt Q9UGP8
Wiki SEC63
Yeast and human SEC63 share 25.6% amino acid identity. Western blot analysis detected SEC63 at an apparent molecular mass of 83 kD in HeLa cell extracts and dog pancreatic microsomes. Subcellular fractionation indicated the SEC63 is an integral ER membrane protein. Protease protection experiments indicated that both the N and C termini of canine Sec63 are oriented toward the cytosol, with the DnaJ domain contained within the ER lumen, suggesting that the first hydrophobic stretch does not traverse the ER membrane.Western blot analysis detected Sec63 in all bovine and rat tissues examined. Immunofluorescence analysis of human hepatoma cells indicated that SEC63 and SEC62 colocalized with endoplasmic reticulum proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SEC63 Homolog (SEC63) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SEC63 Homolog (SEC63) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SEC63 Homolog (SEC63) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SEC63 Homolog (SEC63) CLIA Kit Customized Service Offer
n/a ELISA Kit for SEC63 Homolog (SEC63) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SEC63 Homolog (SEC63) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SEC63 Homolog (SEC63) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SEC63 Homolog (SEC63) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SEC63 Homolog (SEC63) CLIA Kit Customized Service Offer
n/a ELISA Kit for SEC63 Homolog (SEC63) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SEC63 Homolog (SEC63) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SEC63 Homolog (SEC63) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SEC63 Homolog (SEC63) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SEC63 Homolog (SEC63) CLIA Kit Customized Service Offer
n/a ELISA Kit for SEC63 Homolog (SEC63) ELISA Kit Customized Service Offer
  1. "Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog."Biol. Chem. 380:1133-1138(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Mammalian Sec61 is associated with Sec62 and Sec63."J. Biol. Chem. 275:14550-14557(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations in SEC63 cause autosomal dominant polycystic liver disease." Nat. Genet. 36:575-577(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]