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Triggering Receptor Expressed On Myeloid Cells Like Protein 2 (TREML2)

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TLT2; C6orf76; TREM-Like Transcript 2

Triggering Receptor Expressed On Myeloid Cells Like Protein 2 (TREML2)
CCC N984
HGNC 21092
MGI 2147038
PubMed 19544488
RGD 1587039
UniProt Q5T2D2
TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 and TREM2, but it has distinct structural and functional properties.
The 321-amino acid protein has a calculated molecular mass of 35 kD. It contains an N-terminal leader sequence, followed by an IgV domain with 2 N-glycosylation sites, a transmembrane domain, and a short C-terminal cytoplasmic domain. The cytoplasmic domain has a tyr residue (Y315) within a potential endocytosis motif (YxxV) and another tyr residue (Y297) within a potent YxxC motif. Both tyr motifs are implicated in STAT3 recruitment and activation. The transmembrane domain of TLT2 lacks charged residues required for interaction with DAP12 (TYROBP).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Triggering Receptor Expressed On Myeloid Cells Like Protein 2 (TREML2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Triggering Receptor Expressed On Myeloid Cells Like Protein 2 (TREML2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Triggering Receptor Expressed On Myeloid Cells Like Protein 2 (TREML2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Triggering Receptor Expressed On Myeloid Cells Like Protein 2 (TREML2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Triggering Receptor Expressed On Myeloid Cells Like Protein 2 (TREML2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Triggering Receptor Expressed On Myeloid Cells Like Protein 2 (TREML2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Triggering Receptor Expressed On Myeloid Cells Like Protein 2 (TREML2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Triggering Receptor Expressed On Myeloid Cells Like Protein 2 (TREML2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Triggering Receptor Expressed On Myeloid Cells Like Protein 2 (TREML2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Triggering Receptor Expressed On Myeloid Cells Like Protein 2 (TREML2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Triggering Receptor Expressed On Myeloid Cells Like Protein 2 (TREML2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Triggering Receptor Expressed On Myeloid Cells Like Protein 2 (TREML2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Triggering Receptor Expressed On Myeloid Cells Like Protein 2 (TREML2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Triggering Receptor Expressed On Myeloid Cells Like Protein 2 (TREML2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Triggering Receptor Expressed On Myeloid Cells Like Protein 2 (TREML2) ELISA Kit Customized Service Offer
  1. "The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44."Eur. J. Immunol. 33:567-577(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses."Proc. Natl. Acad. Sci. U.S.A. 105:10495-10500(2008) [PubMed] [Europe PMC] [Abstract]
  7. ErratumProc. Natl. Acad. Sci. U.S.A. 105:14744-14744(2008)