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AlkB, Alkylation Repair Homolog 7 (ALKBH7)

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SPATA11; ABH7; Spermatogenesis Associated 11; Spermatogenesis cell proliferation-related protein; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial

AlkB, Alkylation Repair Homolog 7 (ALKBH7)
CCC N963
HGNC 21306
MGI 1913650
PubMed 23666923
RGD 1598126
UniProt Q9BT30
By database analysis to identify sequences similar to ABH genes, followed by PCR of a testis cDNA library, Tsujikawa et al. (2007) cloned ALKBH7, which they called ABH7. The deduced 221-amino acid protein has a C-terminal AlkB homology domain that is predicted to function as a 2-oxoglutarate- and Fe(II)-dependent oxygenase domain. Quantitative real-time PCR detected variable ABH7 expression in all 16 tissues examined, with highest expression in pancreas, followed by spleen, prostate, ovary, and placenta. Fluorescence-tagged ABH7 was expressed in both the cytoplasm and nucleus of transfected HeLa cells.Hartz (2010) mapped the ALKBH7 gene to chromosome 19p13.3 based on an alignment of the ALKBH7 sequence with the genomic sequence (GRCh37).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AlkB, Alkylation Repair Homolog 7 (ALKBH7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AlkB, Alkylation Repair Homolog 7 (ALKBH7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AlkB, Alkylation Repair Homolog 7 (ALKBH7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AlkB, Alkylation Repair Homolog 7 (ALKBH7) CLIA Kit Customized Service Offer
n/a ELISA Kit for AlkB, Alkylation Repair Homolog 7 (ALKBH7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AlkB, Alkylation Repair Homolog 7 (ALKBH7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AlkB, Alkylation Repair Homolog 7 (ALKBH7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AlkB, Alkylation Repair Homolog 7 (ALKBH7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AlkB, Alkylation Repair Homolog 7 (ALKBH7) CLIA Kit Customized Service Offer
n/a ELISA Kit for AlkB, Alkylation Repair Homolog 7 (ALKBH7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AlkB, Alkylation Repair Homolog 7 (ALKBH7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AlkB, Alkylation Repair Homolog 7 (ALKBH7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AlkB, Alkylation Repair Homolog 7 (ALKBH7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AlkB, Alkylation Repair Homolog 7 (ALKBH7) CLIA Kit Customized Service Offer
n/a ELISA Kit for AlkB, Alkylation Repair Homolog 7 (ALKBH7) ELISA Kit Customized Service Offer
  1. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Expression and sub-cellular localization of human ABH family molecules."J. Cell. Mol. Med. 11:1105-1116(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis."Genes Dev. 27:1089-1100(2013) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "The atomic-resolution structure of human Alkb homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolism."J. Biol. Chem. 289:27924-27936(2014) [PubMed] [Europe PMC] [Abstract]