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NLR Family, Pyrin Domain Containing Protein 11 (NLRP11)

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NALP11; PYPAF6; NOD17; PAN10; CLR19.6; Nucleotide-binding oligomerization domain protein 17; PAAD-and NACHT domain-containing protein 10

NLR Family, Pyrin Domain Containing Protein 11 (NLRP11)
CCC N949
HGNC 22945
PubMed 12563287
UniProt P59045
Wiki NLRP11
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region.
The long NALP, NALP1, also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases via their involvement in multiprotein complexes called inflammasomes. The 1,033-amino acid NALP11 protein has the typical PYD-NACHT-LRR domain structure found in the NALP family.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NLR Family, Pyrin Domain Containing Protein 11 (NLRP11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NLR Family, Pyrin Domain Containing Protein 11 (NLRP11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NLR Family, Pyrin Domain Containing Protein 11 (NLRP11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NLR Family, Pyrin Domain Containing Protein 11 (NLRP11) CLIA Kit Customized Service Offer
n/a ELISA Kit for NLR Family, Pyrin Domain Containing Protein 11 (NLRP11) ELISA Kit Customized Service Offer
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  2. "Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product."Biochem. Biophys. Res. Commun. 302:575-580(2003) [PubMed] [Europe PMC] [Abstract]
  3. "NALPs: a novel protein family involved in inflammation."Nat. Rev. Mol. Cell Biol. 4:95-104(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]