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Vitamin K Epoxide Reductase Complex Subunit 1 Like Protein 1 (VKORC1L1)

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Vitamin K Epoxide Reductase Complex Subunit 1 Like Protein 1 (VKORC1L1)
CCC N944
HGNC 21492
MGI 1916818
PubMed 23928358
RGD 1303249
UniProt Q8N0U8
By database searching with the sequence of VKORC1 as query, Rost et al. (2004) identified VKORC1L1. The deduced 176-amino acid protein shares 50% identity with VKORC1 and approximately 97% identity with mouse and rat Vkorc1l1. Rost et al. (2004) also identified a VKORC1L1 pseudogene.
VKORC1 haplotype groups A and B explained approximately 25% of the variance in dose. Asian Americans had a higher proportion of group A haplotypes and African Americans a higher proportion of group B haplotypes. VKORC1 mRNA levels varied according to the haplotype combination. Thus the molecular mechanism of this warfarin dose response appears to be regulated at the transcriptional level.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vitamin K Epoxide Reductase Complex Subunit 1 Like Protein 1 (VKORC1L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vitamin K Epoxide Reductase Complex Subunit 1 Like Protein 1 (VKORC1L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vitamin K Epoxide Reductase Complex Subunit 1 Like Protein 1 (VKORC1L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vitamin K Epoxide Reductase Complex Subunit 1 Like Protein 1 (VKORC1L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vitamin K Epoxide Reductase Complex Subunit 1 Like Protein 1 (VKORC1L1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vitamin K Epoxide Reductase Complex Subunit 1 Like Protein 1 (VKORC1L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vitamin K Epoxide Reductase Complex Subunit 1 Like Protein 1 (VKORC1L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vitamin K Epoxide Reductase Complex Subunit 1 Like Protein 1 (VKORC1L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vitamin K Epoxide Reductase Complex Subunit 1 Like Protein 1 (VKORC1L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vitamin K Epoxide Reductase Complex Subunit 1 Like Protein 1 (VKORC1L1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vitamin K Epoxide Reductase Complex Subunit 1 Like Protein 1 (VKORC1L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vitamin K Epoxide Reductase Complex Subunit 1 Like Protein 1 (VKORC1L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vitamin K Epoxide Reductase Complex Subunit 1 Like Protein 1 (VKORC1L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vitamin K Epoxide Reductase Complex Subunit 1 Like Protein 1 (VKORC1L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vitamin K Epoxide Reductase Complex Subunit 1 Like Protein 1 (VKORC1L1) ELISA Kit Customized Service Offer
  1. "Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2."Nature 427:537-541(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function."J. Biol. Chem. 286:15085-15094(2011) [PubMed] [Europe PMC] [Abstract]
  8. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  9. "VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy."J. Biol. Chem. 288:28733-28742(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration."J. Biol. Chem. 289:9396-9407(2014) [PubMed] [Europe PMC] [Abstract]