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Leucine Rich Repeat Containing Protein 16A (LRRC16A)

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LRRC16; CARMIL

Leucine Rich Repeat Containing Protein 16A (LRRC16A)
CCC N936
HGNC 21581
MGI 1915982
PubMed 21677718
RGD 1306623
UniProt Q5VZK9
Wiki LRRC16A
The high-affinity binding between Carmil and CP decreased the affinity of CP for actin barbed ends. Carmil had no effect on actin capping by gelsolin. Mutation analysis confirmed that the central CP-binding domain was necessary and sufficient to inhibit actin capping by CP. Addition of Carmil to rabbit neutrophil extracts increased the rate and extent of Arp2/Arp3 or spectrin -actin seed-induced actin polymerization. Decreasing Carmil levels in human glioblastoma cells by small interfering RNA lowered the F-actin level and slowed cell migration through a mechanism that included decreased lamellipodia protrusion. Wildtype Carmil, but not a Carmil mutant lacking the CP-binding domain, reversed these effects. Overexpression of Carmil in glioblastoma cells increased the fraction of cells with large lamellipodia

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucine Rich Repeat Containing Protein 16A (LRRC16A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucine Rich Repeat Containing Protein 16A (LRRC16A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucine Rich Repeat Containing Protein 16A (LRRC16A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucine Rich Repeat Containing Protein 16A (LRRC16A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucine Rich Repeat Containing Protein 16A (LRRC16A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucine Rich Repeat Containing Protein 16A (LRRC16A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucine Rich Repeat Containing Protein 16A (LRRC16A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucine Rich Repeat Containing Protein 16A (LRRC16A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucine Rich Repeat Containing Protein 16A (LRRC16A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucine Rich Repeat Containing Protein 16A (LRRC16A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucine Rich Repeat Containing Protein 16A (LRRC16A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucine Rich Repeat Containing Protein 16A (LRRC16A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucine Rich Repeat Containing Protein 16A (LRRC16A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucine Rich Repeat Containing Protein 16A (LRRC16A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucine Rich Repeat Containing Protein 16A (LRRC16A) ELISA Kit Customized Service Offer
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  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Distinct roles for CARMIL isoforms in cell migration."Mol. Biol. Cell 20:5290-5305(2009) [PubMed] [Europe PMC] [Abstract]
  4. "Mammalian CARMIL inhibits actin filament capping by capping protein."Dev. Cell 9:209-221(2005) [PubMed] [Europe PMC] [Abstract]
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  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]