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Transmembrane Protein 106B (TMEM106B)

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Transmembrane Protein 106B (TMEM106B)
CCC N905
HGNC 22407
MGI 1919150
PubMed 22895706
RGD 1303037
UniProt Q9NUM4
Wiki TMEM106B
TMEM106B expression in frontal cortex. In silico analysis revealed TMEM106B expression in lymphoblastoid cell lines.TMEM106B gene maps to chromosome 7p21.3.For a discussion of a possible association between variation in the TMEM106B gene and susceptibility to frontotemporal lobar degeneration with TDP43 inclusions.
TMEM106B expression compared to controls, and this expression correlated with presence of the T risk allele; these results were found in both GRN-positive and GRN-negative individuals. The results were compatible with a model in which mutations in GRN may act upstream of TMEM106B expression in increasing the risk for FTLD-TDP.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 106B (TMEM106B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 106B (TMEM106B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 106B (TMEM106B) Polyclonal Antibody Customized Service Offer
Assay Kits SEN905Hu ELISA Kit for Transmembrane Protein 106B (TMEM106B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 106B (TMEM106B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 106B (TMEM106B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 106B (TMEM106B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 106B (TMEM106B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 106B (TMEM106B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 106B (TMEM106B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 106B (TMEM106B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 106B (TMEM106B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 106B (TMEM106B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 106B (TMEM106B) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions." Nat. Genet. 42:234-239(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers." Neurology 76:467-474(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration."J. Biol. Chem. 287:19355-19365(2012) [PubMed] [Europe PMC] [Abstract]
  11. "TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways."J. Neurosci. 32:11213-11227(2012) [PubMed] [Europe PMC] [Abstract]
  12. "The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function."Hum. Mol. Genet. 22:685-695(2013) [PubMed] [Europe PMC] [Abstract]
  13. "TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia."J. Neurochem. 126:781-791(2013) [PubMed] [Europe PMC] [Abstract]
  14. "TMEM106B: a strong FTLD disease modifier."Acta Neuropathol. 127:419-422(2014) [PubMed] [Europe PMC] [Abstract]
  15. "TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions." Acta Neuropathol. 127:407-418(2014) [PubMed] [Europe PMC] [Abstract]
  16. "TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia." Acta Neuropathol. 127:397-406(2014) [PubMed] [Europe PMC] [Abstract]
  17. "The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes."EMBO J. 33:450-467(2014) [PubMed] [Europe PMC] [Abstract]