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Cation Channel, Sperm Associated 1 (CATSPER1)

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Cation Channel, Sperm Associated 1 (CATSPER1)
CCC N898
HGNC 17116
MGI 2179947
PubMed 19344877
RGD 1593515
UniProt Q8NEC5
Wiki CatSper1
CATSPER is a putative sperm cation channel whose amino acid sequence most closely resembles a single 6-transmembrane-spanning repeat of the voltage-dependent calcium channel 4-repeat structure. CATSPER is vital to cAMP-mediated calcium influx in sperm, sperm motility, and fertilization.
The CATSPER gene encodes a protein of 686 amino acids that is expressed exclusively in testis. Human CATSPER exhibits a high degree of homology (55% identity) with its mouse counterpart, especially in the transmembrane domains and histidine-rich region. The transmembrane domains share 81% identity and the pore regions 89% identity. current is not present in spermatozoa lacking the sperm-specific putative ion channel protein Catsper1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cation Channel, Sperm Associated 1 (CATSPER1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cation Channel, Sperm Associated 1 (CATSPER1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cation Channel, Sperm Associated 1 (CATSPER1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cation Channel, Sperm Associated 1 (CATSPER1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cation Channel, Sperm Associated 1 (CATSPER1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cation Channel, Sperm Associated 1 (CATSPER1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cation Channel, Sperm Associated 1 (CATSPER1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cation Channel, Sperm Associated 1 (CATSPER1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cation Channel, Sperm Associated 1 (CATSPER1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cation Channel, Sperm Associated 1 (CATSPER1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cation Channel, Sperm Associated 1 (CATSPER1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cation Channel, Sperm Associated 1 (CATSPER1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cation Channel, Sperm Associated 1 (CATSPER1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cation Channel, Sperm Associated 1 (CATSPER1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cation Channel, Sperm Associated 1 (CATSPER1) ELISA Kit Customized Service Offer
  1. "A sperm ion channel required for sperm motility and male fertility."Nature 413:603-609(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility."Hum. Reprod. 19:124-128(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa."Asian J. Androl. 8:301-306(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity."J. Biol. Chem. 281:22332-22341(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility."Mol. Hum. Reprod. 13:299-306(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Human male infertility caused by mutations in the CATSPER1 channel protein."Am. J. Hum. Genet. 84:505-510(2009) [PubMed] [Europe PMC] [Abstract]
  9. "The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm."Nature 471:382-386(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Progesterone activates the principal Ca2+ channel of human sperm."Nature 471:387-391(2011) [PubMed] [Europe PMC] [Abstract]