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Transmembrane Protein 185A (TMEM185A)

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FAM11A; CXorf13; Family With Sequence Similarity 11 Member A

Transmembrane Protein 185A (TMEM185A)
CCC N897
HGNC 17125
PubMed 17683067
RGD 1563037
UniProt Q8NFB2
The FAM11A gene originates from the CpG island of the fragile site FRAXF and contains the FRAXF CGG repeat in its 5-prime untranslated region. Expansion of the FRAXF CGG repeat and consequent methylation of the CpG island results in transcriptional silencing of the FAM11A gene.
In 5 individuals who exhibited fragile sites in distal Xq, a 5-kb EcoRI fragment derived from a cosmid coincident with the cytogenetic anomaly detected expanded, methylated, and unstable sequences; these individuals had normal repeat lengths at both FRAXA and FRAXE. PCR and sequence analysis of chromosomes from the general population indicated that the repeat is polymorphic (6 to 29 triplets) and is stable upon transmission.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 185A (TMEM185A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 185A (TMEM185A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 185A (TMEM185A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 185A (TMEM185A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 185A (TMEM185A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 185A (TMEM185A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 185A (TMEM185A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 185A (TMEM185A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 185A (TMEM185A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 185A (TMEM185A) ELISA Kit Customized Service Offer
  1. "A novel gene, FAM11A, associated with the FRAXF CpG island is transcriptionally silent in FRAXF full mutation."Eur. J. Hum. Genet. 10:767-772(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor."J. Neurochem. 91:1007-1017(2004) [PubMed] [Europe PMC] [Abstract]