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NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 13 (NDUFa13)

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CGI39; CDA016; GRIM19; B16.6; Complex I B16.6 Subunit; Gene associated with retinoic and interferon-induced mortality 19 protein; NADH-ubiquinone oxidoreductase B16.6 subunit

NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 13 (NDUFa13)
CCC N887
HGNC 17194
MGI 1914434
PubMed 12837546
RGD 1565358
UniProt Q9P0J0
Wiki NDUFA13
GRIM19 showed a punctate distribution and colocalized with endogenous mitochondrial proteins. Mutation analysis indicated that the N terminus of GRIM19 harbors the mitochondrial localization sequence.
The deduced 144-amino acid protein has a calculated molecular mass of 16 kD. Northern blot analysis detected GRIM19 in all adult and fetal tissues examined, with highest levels in adult heart, skeletal muscle, liver, kidney, and placenta, and in fetal liver, spleen, and bone marrow. SDS-PAGE of in vitro translated cDNA indicated that GRIM19 has an apparent molecular mass of about 16 kD. Immunofluorescence microscopy localized GRIM19 to the nucleoplasm of transfected HeLa cells, with some punctate cytoplasmic staining.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 13 (NDUFa13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 13 (NDUFa13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 13 (NDUFa13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 13 (NDUFa13) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 13 (NDUFa13) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 13 (NDUFa13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 13 (NDUFa13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 13 (NDUFa13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 13 (NDUFa13) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 13 (NDUFa13) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 13 (NDUFa13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 13 (NDUFa13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 13 (NDUFa13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 13 (NDUFa13) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 13 (NDUFa13) ELISA Kit Customized Service Offer
  1. "Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach."J. Biol. Chem. 275:33416-33426(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus interacts with a cell death regulator, GRIM19, and inhibits interferon/retinoic acid-induced cell death."J. Virol. 76:8797-8807(2002) [PubMed] [Europe PMC] [Abstract]
  8. "GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction."EMBO J. 22:1325-1335(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
  10. "The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3."Proc. Natl. Acad. Sci. U.S.A. 100:9342-9347(2003) [PubMed] [Europe PMC] [Abstract]
  11. "GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I."Mol. Cell. Biol. 24:8447-8456(2004) [PubMed] [Europe PMC] [Abstract]
  12. "GW112, a novel antiapoptotic protein that promotes tumor growth."Cancer Res. 64:2474-2481(2004) [PubMed] [Europe PMC] [Abstract]
  13. "GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells."J. Biol. Chem. 280:19021-19026(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid."Br. J. Cancer 92:1892-1898(2005) [PubMed] [Europe PMC] [Abstract]