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RAB11 Family Interacting Protein 3 (RAB11FIP3)

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Eferin; ARFO1; Rab11-FIP3; Arfophilin-1; EF hands-containing Rab-interacting protein

RAB11 Family Interacting Protein 3 (RAB11FIP3)
CCC N883
HGNC 17224
MGI 2444431
PubMed 11481332
UniProt O75154
Wiki RAB11FIP3
RAB11FIP3 contains a putative C-terminal ezrin-radixin-moesin (ERM) motif and a C-terminal 18-amino acid amphipathic alpha helix that serves as the RAB11-binding domain. Other than in the RAB11-binding domains, RAB11FIP2 and rabbit Rab11fip1 share no significant identity. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases. The deduced protein contains 756 amino acids. RT-PCR analysis detected high expression of RAB11FIP3 in all tissues examined except spleen, which showed low expression.The deduced protein contains an N-terminal proline-rich region and 2 EF-hand motifs. Fluorescence-tagged eferin showed a predominantly perinuclear staining pattern in transfected normal rat kidney cells and localized to the apical pole in transfected canine kidney cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB11 Family Interacting Protein 3 (RAB11FIP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB11 Family Interacting Protein 3 (RAB11FIP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB11 Family Interacting Protein 3 (RAB11FIP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB11 Family Interacting Protein 3 (RAB11FIP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB11 Family Interacting Protein 3 (RAB11FIP3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB11 Family Interacting Protein 3 (RAB11FIP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB11 Family Interacting Protein 3 (RAB11FIP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB11 Family Interacting Protein 3 (RAB11FIP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB11 Family Interacting Protein 3 (RAB11FIP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB11 Family Interacting Protein 3 (RAB11FIP3) ELISA Kit Customized Service Offer
  1. "Identification of a novel Rab11/25 binding domain present in eferin and rip proteins."J. Biol. Chem. 276:38966-38970(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries."Int. J. Cancer 106:244-251(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and characterization of a family of Rab11-interacting proteins."J. Biol. Chem. 276:39067-39075(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells."Biochem. Biophys. Res. Commun. 299:770-779(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis."Biochem. Biophys. Res. Commun. 319:83-94(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis."EMBO J. 24:3389-3399(2005) [PubMed] [Europe PMC] [Abstract]
  12. "The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis."Mol. Biol. Cell 16:849-860(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular characterization of Rab11-FIP3 binding to ARF GTPases."Eur. J. Cell Biol. 86:417-431(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene."Proc. Natl. Acad. Sci. U.S.A. 104:1236-1241(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment."Traffic 8:414-430(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis."EMBO J. 27:1791-1803(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Rab11-FIP3 is a Rab11-binding protein that regulates breast cancer cell motility by modulating the actin cytoskeleton."Eur. J. Cell Biol. 88:325-341(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Rab11-FIP3 is a cell cycle-regulated phosphoprotein."BMC Cell Biol. 13:4-4(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes."J. Mol. Biol. 364:121-135(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1."Proc. Natl. Acad. Sci. U.S.A. 103:15416-15421(2006) [PubMed] [Europe PMC] [Abstract]