LSM4 Homolog (LSM4)
[Edit]YER112W; GRP; Glycine-rich protein; U6 Small Nuclear RNA Associated; U6 snRNA-associated Sm-like protein LSm4
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Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family. Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop.
Lsm2, Lsm3, Lsm4, and Lsm8 are essential for vegetative growth. Lsm5, Lsm6, and Lsm7 are not essential for growth; however, their disruptions lead to slow growth especially at elevated temperature. The levels of the U6 snRNA were strongly reduced in the strains harboring the Lsm5, Lsm6, and Lsm7 disruptions. Lsm1 and Lsm9 are dispensable for vegetative growth, but Lsm1 is required for optimal vegetative growth at 30 degrees and is temperature sensitive.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant LSM4 Homolog (LSM4) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to LSM4 Homolog (LSM4) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to LSM4 Homolog (LSM4) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for LSM4 Homolog (LSM4) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for LSM4 Homolog (LSM4) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant LSM4 Homolog (LSM4) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to LSM4 Homolog (LSM4) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to LSM4 Homolog (LSM4) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for LSM4 Homolog (LSM4) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for LSM4 Homolog (LSM4) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant LSM4 Homolog (LSM4) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to LSM4 Homolog (LSM4) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to LSM4 Homolog (LSM4) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for LSM4 Homolog (LSM4) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for LSM4 Homolog (LSM4) | ELISA Kit Customized Service Offer |
- "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin."EMBO J. 18:3451-3462(1999) [PubMed] [Europe PMC] [Abstract]
- "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro."EMBO J. 18:5789-5802(1999) [PubMed] [Europe PMC] [Abstract]
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- , Submitted (JUL-2007) to UniProtKB
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]