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Osterix (OSX)

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Sp7 Transcription Factor; Specificity Protein 7; Zinc finger protein osterix

Osterix (OSX)
CCC N863
HGNC 17321
MGI 2159409
PubMed 16041384
RGD 631377
UniProt Q8TDD2
Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. OSX is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.The deduced 431-amino acid protein has a calculated molecular mass of 45 kD and contains an N-terminal proline-rich domain and 3 consecutive C-terminal C2H2 zinc finger motifs. Mouse and human SP7 share 95% amino acid identity. The lack of a glutamine-rich domain and the presence of a proline-rich domain distinguish SP7 from other SP family proteins. In situ hybridization of human embryonic tissues revealed SP7 expression in osteoblastic cells of the appendicular and craniofacial skeleton.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN863Hu01 Recombinant Osterix (OSX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAN863Hu21 Monoclonal Antibody to Osterix (OSX) WB; IHC; ICC; IP.
PAN863Hu01 Polyclonal Antibody to Osterix (OSX) WB; IHC; ICC; IP.
Assay Kits SEN863Hu ELISA Kit for Osterix (OSX) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN863Mu01 Recombinant Osterix (OSX) Positive Control; Immunogen; SDS-PAGE; WB.
RPN863Mu02 Recombinant Osterix (OSX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAN863Mu01 Polyclonal Antibody to Osterix (OSX) WB; IHC; ICC; IP.
PAN863Mu02 Polyclonal Antibody to Osterix (OSX) WB; IHC; ICC; IP.
Assay Kits SEN863Mu ELISA Kit for Osterix (OSX) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Osterix (OSX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Osterix (OSX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Osterix (OSX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Osterix (OSX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Osterix (OSX) ELISA Kit Customized Service Offer
  1. "The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation."Cell 108:17-29(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells."BMC Genomics 4:43-43(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning, structure, expression, and chromosomal localization of the human Osterix (SP7) gene."Gene 341:101-110(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a frameshift mutation in Osterix in a patient with recessive osteogenesis imperfecta."Am. J. Hum. Genet. 87:110-114(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of Osterix protein stability and physiological role in osteoblast differentiation."PLoS ONE 8:E56451-E56451(2013) [PubMed] [Europe PMC] [Abstract]