≡

Nucleolar Preribosomal Associated Protein 1 (NPA1)

[Edit]

URB1; C21orf108; Ribosome Biogenesis 1 Homolog; Unhealthy Ribosome Biogenesis Protein 1; Nucleolar protein 254 kDa; URB1 ribosome biogenesis 1 homolog

Nucleolar Preribosomal Associated Protein 1 (NPA1)
CCC N859
HGNC 17344
MGI 2146468
PubMed 19472194
RGD 1304621
UniProt O60287
Npa1 accumulated in the immediate vicinity of the dense fibrillar component of the nucleolus in yeast. Npa1 was predominantly associated with the 27SA2 pre-rRNA, the RNA component of the earliest pre-60S ribosomal particles. Absence of Npa1 perturbed the pre-rRNA processing pathway leading to 5.8S and 25S rRNA. Npa1 interacted with 8 putative helicases as well as with other nucleolar factors.
The 3-prime UTR contains Alu sequences and other repetitive elements. RT-PCR detected highest NPA1 expression in kidney, followed by liver, skeletal muscle, prostate, ovary, heart, brain, placenta, lung, testis, pancreas, and spleen. Little to no expression was detected in thymus and small intestine.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Preribosomal Associated Protein 1 (NPA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Preribosomal Associated Protein 1 (NPA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Preribosomal Associated Protein 1 (NPA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Preribosomal Associated Protein 1 (NPA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Preribosomal Associated Protein 1 (NPA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Preribosomal Associated Protein 1 (NPA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Preribosomal Associated Protein 1 (NPA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Preribosomal Associated Protein 1 (NPA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Preribosomal Associated Protein 1 (NPA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Preribosomal Associated Protein 1 (NPA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Preribosomal Associated Protein 1 (NPA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Preribosomal Associated Protein 1 (NPA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Preribosomal Associated Protein 1 (NPA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Preribosomal Associated Protein 1 (NPA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Preribosomal Associated Protein 1 (NPA1) ELISA Kit Customized Service Offer
  1. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21."Gene 247:215-232(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Functional proteomic analysis of human nucleolus."Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
  7. "NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47."Nucleic Acids Res. 34:4593-4608(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]