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Cytochrome P450 3A43 (CYP3A43)

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Cytochrome P450 Family 3 Subfamily A Polypeptide 43

Cytochrome P450 3A43 (CYP3A43)
CCC N847
HGNC 17450
MGI 1930638
PubMed 11160876
RGD 628709
UniProt Q9HB55
Wiki CYP3A43
CYP3A43 encodes a member of the cytochrome P450 superfamily of enzymes. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms.
The deduced protein is 76%, 76%, and 72% identical to CYP3A4, CYP3A5, and CYP3A7, respectively. Real-time PCR in 10 different livers revealed that CYP3A43 is expressed at 0.1% and 2% of the levels of CYP3A4 and CYP3A5.SDS-PAGE and Western blot analysis showed expression of an approximately 55-kD protein. Functional analysis indicated that, under appropriate conditions, CYP3A43 exhibits low but reproducible testosterone 6-beta-hydroxylase activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 3A43 (CYP3A43) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 3A43 (CYP3A43) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 3A43 (CYP3A43) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 3A43 (CYP3A43) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 3A43 (CYP3A43) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 3A43 (CYP3A43) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 3A43 (CYP3A43) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 3A43 (CYP3A43) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 3A43 (CYP3A43) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 3A43 (CYP3A43) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 3A43 (CYP3A43) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 3A43 (CYP3A43) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 3A43 (CYP3A43) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 3A43 (CYP3A43) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 3A43 (CYP3A43) ELISA Kit Customized Service Offer
  1. "cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450."Mol. Pharmacol. 59:386-392(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and tissue distribution of a novel human cytochrome P450 of the CYP3A subfamily, CYP3A43."Biochem. Biophys. Res. Commun. 281:1349-1355(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene."Pharmacogenetics 11:111-121(2001) [PubMed] [Europe PMC] [Abstract]
  4. "First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant."Hum. Mutat. 23:101-101(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Intergenic mRNA molecules resulting from trans-splicing."J. Biol. Chem. 277:5882-5890(2002) [PubMed] [Europe PMC] [Abstract]
  8. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]