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Nucleoside Diphosphate Linked Moiety X-Type Motif 10 (NUDT10)

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DIPP3a; APS2; Nudix Type Motif 10; Diphosphoinositol polyphosphate phosphohydrolase 3-alpha; Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha

Nucleoside Diphosphate Linked Moiety X-Type Motif 10 (NUDT10)
CCC N837
HGNC 17621
MGI 2147931
PubMed 21071540
UniProt Q8NFP7
NUDT10 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates. The ORFs of NUDT10 and NUDT11 have 6 nucleotide differences, leading to 5 silent changes and a single amino acid change (pro89 in NUDT10 and arg89 in NUDT11). Both proteins contain 164 amino acids. PCR analysis detected strong NUDT10 expression in brain and liver. Expression was also detected in heart, placenta, lung, kidney, pancreas, spleen, prostate, testis, and ovary, but not in any other tissue examined. Fluorescence-tagged NUDT10 localized to the cytosol of human embryonic kidney cells and rat pheochromocytoma cells.NUDT10 also hydrolyzed diadenosine hexaphosphate, and it showed a marked preference for adenine over guanine nucleotides.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleoside Diphosphate Linked Moiety X-Type Motif 10 (NUDT10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 10 (NUDT10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 10 (NUDT10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 10 (NUDT10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 10 (NUDT10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleoside Diphosphate Linked Moiety X-Type Motif 10 (NUDT10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 10 (NUDT10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 10 (NUDT10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 10 (NUDT10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 10 (NUDT10) ELISA Kit Customized Service Offer
  1. "An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase."J. Biol. Chem. 277:32730-32738(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases."BMC Biochem. 3:20-20(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate."J. Biol. Chem. 277:47313-47317(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha."Submitted (APR-2010) to the PDB data bank