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RAB Guanine Nucleotide Exchange Factor (RABGEF1)

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RABEX5; RAP1; Rabaptin-5-associated exchange factor for Rab5

RAB Guanine Nucleotide Exchange Factor (RABGEF1)
CCC N832
HGNC 17676
MGI 1929459
PubMed 16533754
RGD 1307295
UniProt Q9UJ41
Wiki RABGEF1
RABGEF1 forms a complex with rabaptin-5 (RABPT5) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A). The deduced 492-amino acid protein has a calculated molecular mass of 57.1 kD and shares significant homology with yeast Vps9, a protein implicated in endocytic traffic. A 60-kD RABGEF1 protein was detected in HeLa cells, bovine brain, and all mouse tissues examined, suggesting that it is ubiquitously expressed.RABGEF1-RABPT5 complex was essential for both homotypic and heterotypic endosome fusions. Both RABGEF1 and RABPT5 bound RAB5 preferentially in the presence of GTP rather than GDP. RABGEF1 displayed specific GDP/GTP exchange activity on RAB5 upon delivery of RAB5 to the membrane.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB Guanine Nucleotide Exchange Factor (RABGEF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB Guanine Nucleotide Exchange Factor (RABGEF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB Guanine Nucleotide Exchange Factor (RABGEF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB Guanine Nucleotide Exchange Factor (RABGEF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB Guanine Nucleotide Exchange Factor (RABGEF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB Guanine Nucleotide Exchange Factor (RABGEF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB Guanine Nucleotide Exchange Factor (RABGEF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB Guanine Nucleotide Exchange Factor (RABGEF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB Guanine Nucleotide Exchange Factor (RABGEF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB Guanine Nucleotide Exchange Factor (RABGEF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB Guanine Nucleotide Exchange Factor (RABGEF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB Guanine Nucleotide Exchange Factor (RABGEF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB Guanine Nucleotide Exchange Factor (RABGEF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB Guanine Nucleotide Exchange Factor (RABGEF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB Guanine Nucleotide Exchange Factor (RABGEF1) ELISA Kit Customized Service Offer
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