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Ras Homolog Gene Family, Member U (RHOU)

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ARHU; WRCH1; CDC42L1; Ryu GTPase; Wnt-1 Responsive Cdc42 Homolog; GTP-Binding Protein Like 1; CDC42-Like GTPase; GTP-Binding Protein SB128

Ras Homolog Gene Family, Member U (RHOU)
CCC N821
HGNC 17794
MGI 1916831
PubMed 11459829
UniProt Q7L0Q8
Wiki Wrch1
WRCH1, like CDC42, can activate PAK1 and JNK1 (MAPK8) and can induce filopodium formation and stress fiber dissolution. Active Wrch1 stimulated quiescent cells to reenter the cell cycle. Overexpression of Wrch1 in mouse mammary epithelial cells induced morphologic transformation that mimics Wnt1-induced transformation.
Human WRCH1 encodes a deduced 258-amino acid protein that shares 92% and 57% sequence identity with mouse Wrch1 and human CDC42, respectively. WRCH1 has features conserved among members of the Rho family of GTPases including GTP and GDP binding domains, the effector domain, and a CAAX lipid modification signal in the C terminus. Wrch1 expression is upregulated in response to a Wnt1 expressing retrovirus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Homolog Gene Family, Member U (RHOU) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Homolog Gene Family, Member U (RHOU) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Homolog Gene Family, Member U (RHOU) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Homolog Gene Family, Member U (RHOU) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Homolog Gene Family, Member U (RHOU) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Homolog Gene Family, Member U (RHOU) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Homolog Gene Family, Member U (RHOU) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Homolog Gene Family, Member U (RHOU) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Homolog Gene Family, Member U (RHOU) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Homolog Gene Family, Member U (RHOU) ELISA Kit Customized Service Offer
  1. "Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1."Genes Dev. 15:1796-1807(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of WRCH1 in human cancer and down-regulation of WRCH1 by beta-estradiol in MCF-7 cells."Int. J. Oncol. 20:777-783(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Novel human, mouse and Xenopus genes encoding a member of the RAS superfamily of low-molecular-weight GTP-binding proteins and its downregulation in W/WV mouse jejunum."J. Gastroenterol. Hepatol. 19:211-217(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Scan of human genome reveals no new loci under ancient balancing selection."Genetics 173:2165-2177(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract].
  6. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  8. "Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif."J. Biol. Chem. 280:33055-33065(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Biochemical analyses of the Wrch atypical Rho family GTPases."Methods Enzymol. 406:11-26(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of a bipartite focal adhesion localization signal in RhoU/Wrch-1, a Rho family GTPase that regulates cell adhesion and migration."Biol. Cell 99:701-716(2007) [PubMed] [Europe PMC] [Abstract]
  11. "The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics."Mol. Cell. Biol. 28:1802-1814(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract]
  13. "ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion."Biochem. Biophys. Res. Commun. 409:96-102(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The crystal structure of RHOUA in the GDP-bound state."Submitted (JUN-2007) to the PDB data bank