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LSM3 Homolog (LSM3)

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SMX4; USS2; U6 snRNA-associated Sm-like protein LSm3

LSM3 Homolog (LSM3)
CCC N816
HGNC 17874
MGI 1914928
PubMed 18329667
RGD 1305971
UniProt P62310
Wiki LSM3
Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.Lsm2, Lsm3, Lsm4, and Lsm8 are essential for vegetative growth. Lsm5, Lsm6, and Lsm7 are not essential for growth; however, their disruptions lead to slow growth especially at elevated temperature. The levels of the U6 snRNA were strongly reduced in the strains harboring the Lsm5, Lsm6, and Lsm7 disruptions. Lsm1 and Lsm9 are dispensable for vegetative growth, but Lsm1 is required for optimal vegetative growth at 30 degrees and is temperature sensitive.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LSM3 Homolog (LSM3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LSM3 Homolog (LSM3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LSM3 Homolog (LSM3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LSM3 Homolog (LSM3) CLIA Kit Customized Service Offer
n/a ELISA Kit for LSM3 Homolog (LSM3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LSM3 Homolog (LSM3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LSM3 Homolog (LSM3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LSM3 Homolog (LSM3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LSM3 Homolog (LSM3) CLIA Kit Customized Service Offer
n/a ELISA Kit for LSM3 Homolog (LSM3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LSM3 Homolog (LSM3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LSM3 Homolog (LSM3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LSM3 Homolog (LSM3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LSM3 Homolog (LSM3) CLIA Kit Customized Service Offer
n/a ELISA Kit for LSM3 Homolog (LSM3) ELISA Kit Customized Service Offer
  1. "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin."EMBO J. 18:3451-3462(1999) [PubMed] [Europe PMC] [Abstract]
  2. "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro."EMBO J. 18:5789-5802(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]