MAS Related GPR Member X2 (MRGPRX2)

[Edit]

MRGX2; Mas-related G-protein coupled receptor member X2

MAS Related GPR Member X2 (MRGPRX2)
Dong et al. (2001) identified, in the mouse and human genomes, a family of G protein-coupled receptors (GPCRs) related to the MAS1 oncogene, including MRGX2. Several pseudogenes were also identified. The predicted MRG proteins contain transmembrane, extracellular, and cytoplasmic domains. A subset of MRGs was expressed in specific subpopulations of sensory neurons that detect painful stimuli. The expression patterns of these genes thus revealed an unexpected degree of molecular diversity among nociceptive neurons. Some MRGs could be specifically activated in heterologous cells by RFamide neuropeptides such as NPFF and NPAF, which are analgesic in vivo. The authors concluded that MRGs may regulate nociceptor function and/or development, including the sensation or modulation of pain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN800Hu01 Recombinant MAS Related GPR Member X2 (MRGPRX2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to MAS Related GPR Member X2 (MRGPRX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MAS Related GPR Member X2 (MRGPRX2) Polyclonal Antibody Customized Service Offer
Assay Kits SEN800Hu ELISA Kit for MAS Related GPR Member X2 (MRGPRX2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MAS Related GPR Member X2 (MRGPRX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MAS Related GPR Member X2 (MRGPRX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MAS Related GPR Member X2 (MRGPRX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MAS Related GPR Member X2 (MRGPRX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for MAS Related GPR Member X2 (MRGPRX2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MAS Related GPR Member X2 (MRGPRX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MAS Related GPR Member X2 (MRGPRX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MAS Related GPR Member X2 (MRGPRX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MAS Related GPR Member X2 (MRGPRX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for MAS Related GPR Member X2 (MRGPRX2) ELISA Kit Customized Service Offer
  1. "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons."Cell 106:619-632(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception."Gene 352:30-35(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes."Gene 540:16-19(2014) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of G protein-coupled receptor genes from the human genome sequence."FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion."J. Biol. Chem. 278:44400-44404(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides."Biochem. Biophys. Res. Commun. 330:1146-1152(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Expression of cortistatin and MrgX2, a specific cortistatin receptor, in human neuroendocrine tissues and related tumours."J. Pathol. 207:336-345(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization."J. Biol. Chem. 286:44739-44749(2011) [PubMed] [Europe PMC] [Abstract]
  10. "PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells."Mol. Pharmacol. 79:1005-1013(2011) [PubMed] [Europe PMC] [Abstract]
  11. "beta-Defensins activate human mast cells via Mas-related gene X2."J. Immunol. 191:345-352(2013) [PubMed] [Europe PMC] [Abstract]
  12. "Complanadine A, a selective agonist for the Mas-related G protein-coupled receptor X2."Bioorg. Med. Chem. Lett. 24:3512-3515(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions."Nature 519:237-241(2015) [PubMed] [Europe PMC] [Abstract]