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Chromosome 11 Open Reading Frame 30 (C11orf30)

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EMSY

Chromosome 11 Open Reading Frame 30 (C11orf30)
CCC N788
HGNC 18071
MGI 1924203
PubMed 14651845
UniProt Q7Z589
Wiki C11orf30
EMSY amplification in 52 (18%) of 285 high-grade papillary serous carcinomas, 4 (15%) of 27 high-grade endometrioid carcinomas, 3 (8%) of 38 clear cell carcinomas, and 3 (30%) of 10 undifferentiated carcinomas. Analysis of chromosome 11q13 amplification in ovarian cancer showed that EMSY localized to the region with the highest frequency of copy number gain.
The deduced 1,322-amino acid protein has a calculated molecular mass of about 160 kD. EMSY has a unique N-terminal 80-amino acid domain that is conserved between several species, including plants. Western blot analysis indicated that endogenous EMSY in the nuclear fraction of a human osteosarcoma cell line had an apparent molecular mass above 160 kD.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromosome 11 Open Reading Frame 30 (C11orf30) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromosome 11 Open Reading Frame 30 (C11orf30) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromosome 11 Open Reading Frame 30 (C11orf30) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromosome 11 Open Reading Frame 30 (C11orf30) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromosome 11 Open Reading Frame 30 (C11orf30) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromosome 11 Open Reading Frame 30 (C11orf30) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromosome 11 Open Reading Frame 30 (C11orf30) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromosome 11 Open Reading Frame 30 (C11orf30) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromosome 11 Open Reading Frame 30 (C11orf30) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromosome 11 Open Reading Frame 30 (C11orf30) ELISA Kit Customized Service Offer
  1. "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer." Cell 115:523-535(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation."J. Biol. Chem. 284:7542-7552(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis."Sci. Signal. 3:RA2-RA2(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69."EMBO Rep. 6:675-680(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structure of the ENT domain of human EMSY."J. Mol. Biol. 350:964-973(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding."Structure 14:703-712(2006) [PubMed] [Europe PMC] [Abstract]