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SWI/SNF Related, Matrix Associated Actin, Dependent Regulator Of Chromatin, A Containing DEAD/H Box (SMARCAD1)

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ETL1; hHEL1; ATP-Dependent Helicase 1

SWI/SNF Related, Matrix Associated Actin, Dependent Regulator Of Chromatin, A Containing DEAD/H Box (SMARCAD1)
CCC N752
HGNC 18398
MGI 95453
PubMed 21820097
RGD 1309640
UniProt Q9H4L7
Wiki SMARCAD1
SMARCAD1 is a member of the SNF subfamily of the helicase protein superfamily that binds to transcriptional start sites of many genes involved in transcriptional regulation.
The deduced 1,027-amino acid protein has a calculated molecular mass of 117 kD and contains all 7 conserved motifs of the SNF2 family, including 2 DEAD/H boxes, a bipartite nuclear localization signal, a homeobox, and 2 leucine zipper motifs. Dot-blot mRNA analysis of human tissues detected ubiquitous SMARCAD1 expression, with highest levels in endocrine tissues, lung, colon, and placenta and abundant expression in adult hematopoietic tissues (spleen, thymus, and lymph nodes) and in all fetal tissues. Northern blot analysis confirmed ubiquitous expression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SWI/SNF Related, Matrix Associated Actin, Dependent Regulator Of Chromatin, A Containing DEAD/H Box (SMARCAD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SWI/SNF Related, Matrix Associated Actin, Dependent Regulator Of Chromatin, A Containing DEAD/H Box (SMARCAD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SWI/SNF Related, Matrix Associated Actin, Dependent Regulator Of Chromatin, A Containing DEAD/H Box (SMARCAD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SWI/SNF Related, Matrix Associated Actin, Dependent Regulator Of Chromatin, A Containing DEAD/H Box (SMARCAD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SWI/SNF Related, Matrix Associated Actin, Dependent Regulator Of Chromatin, A Containing DEAD/H Box (SMARCAD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SWI/SNF Related, Matrix Associated Actin, Dependent Regulator Of Chromatin, A Containing DEAD/H Box (SMARCAD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SWI/SNF Related, Matrix Associated Actin, Dependent Regulator Of Chromatin, A Containing DEAD/H Box (SMARCAD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SWI/SNF Related, Matrix Associated Actin, Dependent Regulator Of Chromatin, A Containing DEAD/H Box (SMARCAD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SWI/SNF Related, Matrix Associated Actin, Dependent Regulator Of Chromatin, A Containing DEAD/H Box (SMARCAD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SWI/SNF Related, Matrix Associated Actin, Dependent Regulator Of Chromatin, A Containing DEAD/H Box (SMARCAD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SWI/SNF Related, Matrix Associated Actin, Dependent Regulator Of Chromatin, A Containing DEAD/H Box (SMARCAD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SWI/SNF Related, Matrix Associated Actin, Dependent Regulator Of Chromatin, A Containing DEAD/H Box (SMARCAD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SWI/SNF Related, Matrix Associated Actin, Dependent Regulator Of Chromatin, A Containing DEAD/H Box (SMARCAD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SWI/SNF Related, Matrix Associated Actin, Dependent Regulator Of Chromatin, A Containing DEAD/H Box (SMARCAD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SWI/SNF Related, Matrix Associated Actin, Dependent Regulator Of Chromatin, A Containing DEAD/H Box (SMARCAD1) ELISA Kit Customized Service Offer
  1. "SMARCAD1, a novel human helicase family-defining member associated with genetic instability: cloning, expression, and mapping to 4q22-q23, a band rich in breakpoints and deletion mutants involved in several human diseases."Genomics 69:162-173(2000) [PubMed] [Europe PMC] [Abstract]
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  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  9. "The novel protein complex with SMARCAD1/KIAA1122 binds to the vicinity of TSS."J. Mol. Biol. 382:257-265(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "A mutation in a skin-specific isoform of SMARCAD1 causes autosomal-dominant adermatoglyphia."Am. J. Hum. Genet. 89:302-307(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1."Mol. Cell 42:285-296(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  18. "The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection."Nature 489:581-584(2012) [PubMed] [Europe PMC] [Abstract]
  19. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]