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Zinc Finger, DHHC-Type Containing Protein 17 (ZDHHC17)

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HIP14; HYPH; DHHC-17; Palmitoyltransferase ZDHHC17; Huntingtin yeast partner H; Huntingtin-interacting protein 14; Putative NF-kappa-B-activating protein 205

Zinc Finger, DHHC-Type Containing Protein 17 (ZDHHC17)
CCC N750
HGNC 18412
MGI 2445110
PubMed 9700202
RGD 1595790
UniProt Q8IUH5
Wiki ZDHHC17
HIP14 has a predicted intracellular DHHC cysteine-rich palmitoyl acyltransferase domain between transmembrane domains 4 and 5. Fluorescence-tagged HIP14L was expressed predominantly in the Golgi complex in transfected canine kidney cells. HIP14 protein is enriched in the brain, shows partial colocalization with htt in the striatum, and is found in medium spiny projection neurons, the subset of neurons affected in Huntington disease.
HIP14 localizes to the Golgi as well as to vesicles in the cytoplasm. Expression of human HIP14 results in rescue of the temperature-sensitive lethality in akr1-delta yeast cells and, furthermore, restores their defect in endocytosis, demonstrating a possible role for HIP14 in intracellular trafficking.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, DHHC-Type Containing Protein 17 (ZDHHC17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, DHHC-Type Containing Protein 17 (ZDHHC17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, DHHC-Type Containing Protein 17 (ZDHHC17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, DHHC-Type Containing Protein 17 (ZDHHC17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, DHHC-Type Containing Protein 17 (ZDHHC17) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, DHHC-Type Containing Protein 17 (ZDHHC17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, DHHC-Type Containing Protein 17 (ZDHHC17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, DHHC-Type Containing Protein 17 (ZDHHC17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, DHHC-Type Containing Protein 17 (ZDHHC17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, DHHC-Type Containing Protein 17 (ZDHHC17) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, DHHC-Type Containing Protein 17 (ZDHHC17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, DHHC-Type Containing Protein 17 (ZDHHC17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, DHHC-Type Containing Protein 17 (ZDHHC17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, DHHC-Type Containing Protein 17 (ZDHHC17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, DHHC-Type Containing Protein 17 (ZDHHC17) ELISA Kit Customized Service Offer
  1. "HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis."Hum. Mol. Genet. 11:2815-2828(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Huntingtin interacts with a family of WW domain proteins."Hum. Mol. Genet. 7:1463-1474(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins."Neuron 44:977-986(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase."Oncogene 23:9230-9237(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport."J. Biol. Chem. 283:33365-33374(2008) [PubMed] [Europe PMC] [Abstract]
  10. "ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization."Mol. Cell. Biol. 29:1459-1471(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Palmitoylation of MPP1 (membrane-palmitoylated protein 1)/p55 is crucial for lateral membrane organization in erythroid cells."J. Biol. Chem. 287:18974-18984(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Identifying tandem Ankyrin repeats in protein structures."BMC Bioinformatics 15:6599-6599(2014) [PubMed] [Europe PMC] [Abstract]
  13. "The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding."Proteins 76:772-777(2009) [PubMed] [Europe PMC] [Abstract]