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Huntingtin Interacting Protein K (HYPK)

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C15orf63

Huntingtin Interacting Protein K (HYPK)
CCC N748
HGNC 18418
MGI 1914943
RGD 1311457
UniProt Q9NX55
Huntington disease (HD) is caused by expansion of a CAG trinucleotide repeat encoding an N-terminal polyglutamine region in huntingtin (HTT) to more than 34 units.
HYPK interacted with the isolated N-terminal region of human huntingtin containing either 16 (H16) or 40 (H40) glutamines. Coexpression of HYPK reduced H40 aggregate formation and H40-induced apoptosis. Purified recombinant HYPK showed chaperone-like activity in vitro against temperature-induced protein aggregates and in vivo against heat-denatured proteins. In cells expressing HYPK and H40, the chaperone-like activity of HYPK against other protein substrates was reduced compared with cells expressing HYPK and H16, apparently due to interaction of HYPK with H40 protein aggregates.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Huntingtin Interacting Protein K (HYPK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Huntingtin Interacting Protein K (HYPK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Huntingtin Interacting Protein K (HYPK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Huntingtin Interacting Protein K (HYPK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Huntingtin Interacting Protein K (HYPK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Huntingtin Interacting Protein K (HYPK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Huntingtin Interacting Protein K (HYPK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Huntingtin Interacting Protein K (HYPK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Huntingtin Interacting Protein K (HYPK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Huntingtin Interacting Protein K (HYPK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Huntingtin Interacting Protein K (HYPK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Huntingtin Interacting Protein K (HYPK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Huntingtin Interacting Protein K (HYPK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Huntingtin Interacting Protein K (HYPK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Huntingtin Interacting Protein K (HYPK) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Huntingtin interacts with a family of WW domain proteins."Hum. Mol. Genet. 7:1463-1474(1998) [PubMed] [Europe PMC] [Abstract]
  6. "HYPK, a Huntingtin interacting protein, reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2a cells and exhibits chaperone-like activity."Hum. Mol. Genet. 17:240-255(2008) [PubMed] [Europe PMC] [Abstract]
  7. "The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation."Mol. Cell. Biol. 30:1898-1909(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]