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Zinc Finger, DHHC-Type Containing Protein 8 (ZDHHC8)

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ZNF378; Probable palmitoyltransferase ZDHHC8

Zinc Finger, DHHC-Type Containing Protein 8 (ZDHHC8)
CCC N744
HGNC 18474
MGI 1338012
PubMed 10574462
RGD 1308875
UniProt Q9ULC8
Wiki ZDHHC8
The 2,839-bp cDNA encoded a 595-amino acid deduced protein. The polymorphism showed differences in transmission distortion between sexes in individuals with schizophrenia. In a sample of 389 families from the U.S. and South Africa, they found that in females with schizophrenia the transmitted:untransmitted ratio was 82:43, whereas in males it was 106:108. Brain morphology of knockout mice seemed normal by gross and histologic evaluation.
Zdhhc8 knockout mice had a sexually dimorphic deficit in prepulse inhibition, a gene dosage-dependent decrease in exploratory activity in a new environment, and a decreased sensitivity to the locomotor stimulatory effects of the psychomimetic drug dizocilpine.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, DHHC-Type Containing Protein 8 (ZDHHC8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, DHHC-Type Containing Protein 8 (ZDHHC8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, DHHC-Type Containing Protein 8 (ZDHHC8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, DHHC-Type Containing Protein 8 (ZDHHC8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, DHHC-Type Containing Protein 8 (ZDHHC8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, DHHC-Type Containing Protein 8 (ZDHHC8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, DHHC-Type Containing Protein 8 (ZDHHC8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, DHHC-Type Containing Protein 8 (ZDHHC8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, DHHC-Type Containing Protein 8 (ZDHHC8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, DHHC-Type Containing Protein 8 (ZDHHC8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, DHHC-Type Containing Protein 8 (ZDHHC8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, DHHC-Type Containing Protein 8 (ZDHHC8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, DHHC-Type Containing Protein 8 (ZDHHC8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, DHHC-Type Containing Protein 8 (ZDHHC8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, DHHC-Type Containing Protein 8 (ZDHHC8) ELISA Kit Customized Service Offer
  1. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8."Hum. Mol. Genet. 13:2991-2995(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia."Nat. Genet. 36:725-731(2004) [PubMed] [Europe PMC] [Abstract]
  8. "No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples." Biol. Psychiatry 58:78-80(2005) [PubMed] [Europe PMC] [Abstract]
  9. "No association was found between a functional SNP in ZDHHC8 and schizophrenia in a Japanese case-control population."Neurosci. Lett. 374:21-24(2005) [PubMed] [Europe PMC] [Abstract]
  10. "The ZDHHC8 gene did not associate with bipolar disorder or schizophrenia."Neurosci. Lett. 390:166-170(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function."Circ. Res. 105:138-147(2009) [PubMed] [Europe PMC] [Abstract]