COBW Domain Containing Protein 3 (CBWD3)

By examining genes arising from intra- and interchromosomal duplications involving the ancestral chromosome 2 fusion site, Fan et al. (2002) identified CBWD1, CBWD2, and CBWD3. No 2 of the 3 CBWD paralogs are identical, but they all encode a deduced 395-amino acid protein containing a cobalamin synthetase W domain.Fan et al. (2002) determined that the CBWD3 gene contains 15 coding exons and spans 59 kb.By genomic sequence analysis, Fan et al. (2002) mapped the CBWD3 gene to chromosome 9q13.Using subtractive hybridization to identify genes upregulated by dopamine in rat cerebral astrocytes, followed by screening a human fetal brain cDNA library, Shi et al. (2001) cloned CBWD1. The deduced protein shares weak homology with the Rhodobacter cobalamin synthesis protein and the Cyanobacterium hydrogenase expression/formation protein hypB.