≡

Kelch Like Protein 9 (KLHL9)

[Edit]

Kelch Like Protein 9 (KLHL9)
CCC N706
HGNC 18732
MGI 2180122
PubMed 17543862
RGD 1304814
UniProt Q9P2J3
KLHL9, KLHL13, and CUL3 interacted directly in a 370-kD protein complex in HeLa cell lysates. The CUL3/KLHL9/KLHL13 complex was the minimum unit required for correct chromosome alignment in metaphase, proper midzone and midbody formation, and completion of cytokinesis. CUL3/KLHL9/KLHL13 acted as an E3 ligase and regulated dynamic localization of the chromosomal passenger protein Aurora B (AURKB) on mitotic chromosomes and accumulation of Aurora B on the central spindle after anaphase onset. Aurora B directly bound the substrate-recognition domains of KLHL9 and KLHL13 in vitro and coimmunoprecipitated with the CUL3/KLHL9/KLHL13 complex during mitosis. Aurora B was ubiquitylated in a CUL3-dependent manner in vivo and by reconstituted CUL3/KLHL9/KLHL13 in vitro.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kelch Like Protein 9 (KLHL9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kelch Like Protein 9 (KLHL9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kelch Like Protein 9 (KLHL9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kelch Like Protein 9 (KLHL9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kelch Like Protein 9 (KLHL9) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kelch Like Protein 9 (KLHL9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kelch Like Protein 9 (KLHL9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kelch Like Protein 9 (KLHL9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kelch Like Protein 9 (KLHL9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kelch Like Protein 9 (KLHL9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kelch Like Protein 9 (KLHL9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kelch Like Protein 9 (KLHL9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kelch Like Protein 9 (KLHL9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kelch Like Protein 9 (KLHL9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kelch Like Protein 9 (KLHL9) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases."Nat. Cell Biol. 5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract]
  4. "A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells."Dev. Cell 12:887-900(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis."J. Cell Biol. 187:791-800(2009) [PubMed] [Europe PMC] [Abstract]