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Ras And Rab Interactor 2 (RIN2)

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RASSF4; Ras association domain family 4; Ras inhibitor JC265; Ras interaction/interference protein 2

Ras And Rab Interactor 2 (RIN2)
CCC N704
HGNC 18750
MGI 1921280
PubMed 20424861
RGD 1305873
UniProt Q8WYP3
RIN2 is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The deduced 895-amino acid protein contains an SH2 domain, 2 proline-rich domains, a RIN homology (RH) domain, a Vps9 domain, and a Ras association domain, and has a molecular mass of 116 kD. Northern blot analysis detected a 5.1-kb transcript in most tissues examined, with highest expression in heart and kidney, and lowest expression in spleen and peripheral blood cells.
RIN2 mRNA expression was detected in HeLa and astrocytoma cell lines, but not in the Jurkat or THP1 leukemic cell linesRIN2 self-interacts as a homophilic tetramer that is formed by antiparallel linkage of 2 parallel dimers.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras And Rab Interactor 2 (RIN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras And Rab Interactor 2 (RIN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras And Rab Interactor 2 (RIN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras And Rab Interactor 2 (RIN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras And Rab Interactor 2 (RIN2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras And Rab Interactor 2 (RIN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras And Rab Interactor 2 (RIN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras And Rab Interactor 2 (RIN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras And Rab Interactor 2 (RIN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras And Rab Interactor 2 (RIN2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras And Rab Interactor 2 (RIN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras And Rab Interactor 2 (RIN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras And Rab Interactor 2 (RIN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras And Rab Interactor 2 (RIN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras And Rab Interactor 2 (RIN2) ELISA Kit Customized Service Offer
  1. "A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5."J. Biol. Chem. 277:3412-3418(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae."Proc. Natl. Acad. Sci. U.S.A. 88:2913-2917(1991) [PubMed] [Europe PMC] [Abstract]
  6. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  7. "RIN2 deficiency results in macrocephaly, alopecia, cutis laxa, and scoliosis: MACS syndrome." Am. J. Hum. Genet. 85:254-263(2009) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]