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cAMP Responsive Element Binding Protein 3 Like Protein 3 (CREB3L3)

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CREBH; Transcription factor CREB-H

cAMP Responsive Element Binding Protein 3 Like Protein 3 (CREB3L3)
CCC N687
HGNC 18855
MGI 2384786
PubMed 22262056
RGD 1308152
UniProt Q68CJ9
CREB3L3 is a liver-specific transcription factor and member of the CREB/ATF transcription factor family. The deduced 463-amino acid protein contains a C-terminal b-ZIP domain, a putative transmembrane domain, a leucine zipper domain, and a KDEL-like sequence. Northern blot analysis of human tissues detected a 2.5-kb transcript exclusively in liver. Fluorescence microscopy localized CREB3L3 to the endoplasmic reticulum (ER).
CREB3L3 activated transcription of luciferase and box-B reporters via its N-terminal 141 amino acids. Gel mobility shift assay demonstrated that CREB3L3 specifically bound CRE and the box-B element.CREBH plays a critical role in activation of the acute inflammatory response.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant cAMP Responsive Element Binding Protein 3 Like Protein 3 (CREB3L3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to cAMP Responsive Element Binding Protein 3 Like Protein 3 (CREB3L3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to cAMP Responsive Element Binding Protein 3 Like Protein 3 (CREB3L3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for cAMP Responsive Element Binding Protein 3 Like Protein 3 (CREB3L3) CLIA Kit Customized Service Offer
n/a ELISA Kit for cAMP Responsive Element Binding Protein 3 Like Protein 3 (CREB3L3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant cAMP Responsive Element Binding Protein 3 Like Protein 3 (CREB3L3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to cAMP Responsive Element Binding Protein 3 Like Protein 3 (CREB3L3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to cAMP Responsive Element Binding Protein 3 Like Protein 3 (CREB3L3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for cAMP Responsive Element Binding Protein 3 Like Protein 3 (CREB3L3) CLIA Kit Customized Service Offer
n/a ELISA Kit for cAMP Responsive Element Binding Protein 3 Like Protein 3 (CREB3L3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant cAMP Responsive Element Binding Protein 3 Like Protein 3 (CREB3L3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to cAMP Responsive Element Binding Protein 3 Like Protein 3 (CREB3L3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to cAMP Responsive Element Binding Protein 3 Like Protein 3 (CREB3L3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for cAMP Responsive Element Binding Protein 3 Like Protein 3 (CREB3L3) CLIA Kit Customized Service Offer
n/a ELISA Kit for cAMP Responsive Element Binding Protein 3 Like Protein 3 (CREB3L3) ELISA Kit Customized Service Offer
  1. "CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression."Nucleic Acids Res. 29:2154-2162(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma."Nucleic Acids Res. 33:1859-1873(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response."Cell 124:587-599(2006) [PubMed] [Europe PMC] [Abstract]
  8. "N-linked glycosylation is required for optimal proteolytic activation of membrane-bound transcription factor CREB-H."J. Cell Sci. 123:1438-1448(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]