≡

Testis Expressed Protein 1 (TEX1)

[Edit]

THOC3; THO Complex 3

Testis Expressed Protein 1 (TEX1)
CCC N666
HGNC 19072
MGI 1920916
PubMed 20844015
RGD 1311669
UniProt Q96J01
TEX1 is part of the TREX (transcription/export) complex, which includes THO2, HPR1, ALY, and UAP56. By SDS-PAGE analysis of a 45-kD protein from nuclear extracts that interacted in pull-down assays with UAP56, followed by database searching, Strasser et al. (2002) obtained a full-length cDNA encoding TEX1. The predicted protein contains 351 amino acids and is conserved from yeast to humans.
Functional studies in yeast led Strasser et al. (2002) to conclude that the TREX complex is specifically recruited to the transcribing gene and travels with the polymerase during transcriptional elongation. They suggested that it physically links proteins that function in mRNA export or transcription.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Testis Expressed Protein 1 (TEX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Testis Expressed Protein 1 (TEX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Testis Expressed Protein 1 (TEX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Testis Expressed Protein 1 (TEX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Testis Expressed Protein 1 (TEX1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Testis Expressed Protein 1 (TEX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Testis Expressed Protein 1 (TEX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Testis Expressed Protein 1 (TEX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Testis Expressed Protein 1 (TEX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Testis Expressed Protein 1 (TEX1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Testis Expressed Protein 1 (TEX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Testis Expressed Protein 1 (TEX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Testis Expressed Protein 1 (TEX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Testis Expressed Protein 1 (TEX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Testis Expressed Protein 1 (TEX1) ELISA Kit Customized Service Offer
  1. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "TREX is a conserved complex coupling transcription with messenger RNA export."Nature 417:304-308(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Linking transcriptional elongation and messenger RNA export to metastatic breast cancers."Cancer Res. 65:3011-3016(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Recruitment of the human TREX complex to mRNA during splicing."Genes Dev. 19:1512-1517(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Human mRNA export machinery recruited to the 5' end of mRNA."Cell 127:1389-1400(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication."PLoS Pathog. 4:E1000194-E1000194(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA."Nucleic Acids Res. 41:1294-1306(2013) [PubMed] [Europe PMC] [Abstract]