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THO Complex Subunit 2 (THOC2)

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THO2; CXorf3

THO Complex Subunit 2 (THOC2)
CCC N665
HGNC 19073
MGI 2442413
PubMed 23749989
RGD 1561623
UniProt Q8NI27
Wiki THOC2
THO2 is part of the TREX (transcription/export) complex, which includes TEX1, HPR1, ALY , and UAP56.By SDS-PAGE analysis of a 180-kD protein from nuclear extracts that interacted in pull-down assays with UAP56, followed by database searching and PCR screening of a HeLa cell cDNA library, Strasser et al. (2002) obtained a full-length cDNA encoding THO2. The predicted protein contains 1,479 amino acids and is conserved from yeast to humans.
Functional studies in yeast led Strasser et al. (2002) to conclude that the TREX complex is specifically recruited to the transcribing gene and travels with the polymerase during transcriptional elongation. They suggested that it physically links proteins that function in mRNA export or transcription.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant THO Complex Subunit 2 (THOC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to THO Complex Subunit 2 (THOC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to THO Complex Subunit 2 (THOC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for THO Complex Subunit 2 (THOC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for THO Complex Subunit 2 (THOC2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant THO Complex Subunit 2 (THOC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to THO Complex Subunit 2 (THOC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to THO Complex Subunit 2 (THOC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for THO Complex Subunit 2 (THOC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for THO Complex Subunit 2 (THOC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant THO Complex Subunit 2 (THOC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to THO Complex Subunit 2 (THOC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to THO Complex Subunit 2 (THOC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for THO Complex Subunit 2 (THOC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for THO Complex Subunit 2 (THOC2) ELISA Kit Customized Service Offer
  1. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "TREX is a conserved complex coupling transcription with messenger RNA export."Nature 417:304-308(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Linking transcriptional elongation and messenger RNA export to metastatic breast cancers."Cancer Res. 65:3011-3016(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Recruitment of the human TREX complex to mRNA during splicing."Genes Dev. 19:1512-1517(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors."Mol. Cell. Biol. 25:4023-4033(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Human mRNA export machinery recruited to the 5' end of mRNA."Cell 127:1389-1400(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication."PLoS Pathog. 4:E1000194-E1000194(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export."Nat. Commun. 3:1006-1006(2012) [PubMed] [Europe PMC] [Abstract]
  18. ErratumNat. Commun. 4:2377-2377(2013)
  19. "The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export."PLoS ONE 7:E43804-E43804(2012) [PubMed] [Europe PMC] [Abstract]
  20. "Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA."Nucleic Acids Res. 41:1294-1306(2013) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]