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Sodium Leak Channel, Non Selective (NALCN)

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VGCNL1; CanIon; Voltage Gated Channel Like 1

Sodium Leak Channel, Non Selective (NALCN)
CCC N661
HGNC 19082
MGI 2444306
PubMed 24904279
RGD 628710
UniProt Q8IZF0
NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is responsible for the neuronal background sodium leak conductance.
Nalcn encodes a protein with the 4-domain structure of voltage-gated Ca(2+) and Na+ channels. Each domain contains 6 membrane-spanning segments and a pore loop. Northern blot analysis revealed predominant expression in brain, with moderate expression in heart and weak expression in pancreas. Rat and human NALCN share 99% identity. Using in situ hybridization and Northern blot analysis, they found that Nalcn was widely expressed in mouse brain and spinal cord horn neurons, but not in liver, muscle, kidney, or testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sodium Leak Channel, Non Selective (NALCN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sodium Leak Channel, Non Selective (NALCN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sodium Leak Channel, Non Selective (NALCN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sodium Leak Channel, Non Selective (NALCN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sodium Leak Channel, Non Selective (NALCN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sodium Leak Channel, Non Selective (NALCN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sodium Leak Channel, Non Selective (NALCN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sodium Leak Channel, Non Selective (NALCN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sodium Leak Channel, Non Selective (NALCN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sodium Leak Channel, Non Selective (NALCN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sodium Leak Channel, Non Selective (NALCN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sodium Leak Channel, Non Selective (NALCN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sodium Leak Channel, Non Selective (NALCN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sodium Leak Channel, Non Selective (NALCN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sodium Leak Channel, Non Selective (NALCN) ELISA Kit Customized Service Offer
  1. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia." Proc. Natl. Acad. Sci. U.S.A. 99:13675-13680(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm."Cell 129:371-383(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Recessive truncating NALCN mutation in infantile neuroaxonal dystrophy with facial dysmorphism."J. Med. Genet. 50:515-520(2013) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in NALCN cause an autosomal-recessive syndrome with severe hypotonia, speech impairment, and cognitive delay."Am. J. Hum. Genet. 93:721-726(2013) [PubMed] [Europe PMC] [Abstract]