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Transmembrane Protein 55B (TMEM55B)

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C14orf9; PtdIns-4,5-P2 4-Ptase I; Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

Transmembrane Protein 55B (TMEM55B)
CCC N639
HGNC 19299
MGI 2448501
RGD 1307475
UniProt Q86T03
TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate. The deduced 257-amino acid protein contains a central Cx(5)R phosphatase catalytic motif and 2 transmembrane domains near its C terminus, a characteristic of lysosomal transmembrane proteins. RNA dot blot analysis detected expression in all tissues examined. Fluorescence-tagged TMEM55B localized with membrane markers of late endosomes or lysosomes. Endogenous HeLa cell TMEM55B showed a similar distribution.It showed no activity toward other phosphatidylinositol substrates or inositol phosphates tested. Overexpression of TMEM55B in human embryonic kidney cells reduced the total cellular level of PtdIns-4,5-P2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 55B (TMEM55B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 55B (TMEM55B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 55B (TMEM55B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 55B (TMEM55B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 55B (TMEM55B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 55B (TMEM55B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 55B (TMEM55B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 55B (TMEM55B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 55B (TMEM55B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 55B (TMEM55B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 55B (TMEM55B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 55B (TMEM55B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 55B (TMEM55B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 55B (TMEM55B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 55B (TMEM55B) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases."Proc. Natl. Acad. Sci. U.S.A. 102:18854-18859(2005) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]