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Pim-3 Oncogene (PIM3)

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Serine/threonine-protein kinase pim-3

Pim-3 Oncogene (PIM3)
CCC N637
HGNC 19310
MGI 1355297
PubMed 12748291
RGD 620462
UniProt Q86V86
The deduced 326-amino acid protein has a calculated molecular mass of 35.9 kD. PIM3 shares 95% amino acid identity with rodent Pim3 and 57.1% and 44.0% amino acid identity with human PIM1 and PIM2 , respectively.
Northern blot analysis detected a 2.4-kb transcript in heart, skeletal muscle, brain, spleen, kidney, placenta, lung, and peripheral blood leukocytes. Expression was not detected in colon, thymus, liver, and small intestine. Immunohistochemical analysis showed no expression of PIM3 in normal liver, but it localized diffusely in large regenerative nodules and adenomatous hyperplasia, lesions with precancerous potential, adjacent to hepatocellar carcinoma areas. PIM3 was expressed in all hepatoma cell lines examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN637Hu01 Recombinant Pim-3 Oncogene (PIM3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAN637Hu01 Polyclonal Antibody to Pim-3 Oncogene (PIM3) WB; IHC; ICC; IP.
MAN637Hu21 Monoclonal Antibody to Pim-3 Oncogene (PIM3) WB; IHC; ICC; IP.
Assay Kits SEN637Hu ELISA Kit for Pim-3 Oncogene (PIM3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCN637Hu CLIA Kit for Pim-3 Oncogene (PIM3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pim-3 Oncogene (PIM3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pim-3 Oncogene (PIM3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pim-3 Oncogene (PIM3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pim-3 Oncogene (PIM3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pim-3 Oncogene (PIM3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pim-3 Oncogene (PIM3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pim-3 Oncogene (PIM3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pim-3 Oncogene (PIM3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pim-3 Oncogene (PIM3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pim-3 Oncogene (PIM3) ELISA Kit Customized Service Offer
  1. "Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines."Int. J. Cancer 114:209-218(2005) [PubMed] [Europe PMC] [Abstract]
  2. "The transcriptional landscape of the mammalian genome." Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Consistency checks for characterizing protein forms."Comput. Biol. Chem. 27:29-35(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Protein phosphatase 2A regulates the stability of Pim protein kinases."J. Biol. Chem. 278:4800-4805(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines."Cancer Res. 66:6741-6747(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis."Cancer Sci. 98:321-328(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels."Cancer Res. 68:5076-5085(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression."J. Cancer Res. Clin. Oncol. 134:481-488(2008) [PubMed] [Europe PMC] [Abstract]