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DIRAS Family, GTP Binding RAS Like 2 (DIRAS2)

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Di-Ras2; Distinct subgroup of the Ras family member 2; GTP-binding protein Di-Ras2

DIRAS Family, GTP Binding RAS Like 2 (DIRAS2)
CCC N635
HGNC 19323
MGI 1915453
RGD 1305580
UniProt Q96HU8
DIRAS2 belongs to a distinct branch of the functionally diverse Ras superfamily of monomeric GTPases.The deduced 199-amino acid protein contains conserved phosphate/Mg(2+)-binding regions, an effector domain, conserved guanine base-interacting residues, and a C-terminal prenylation motif.
DIRAS2 shares 79% identity with DIRAS1 and 32 to 40% identity with other Ras family members. Northern blot analysis revealed strong expression of a 4.4-kb transcript in whole brain and in most brain regions examined. Expression was weak or undetectable in all other tissues tested.As predicted by these changes, DIRAS1 and DIRAS2 displayed low GTPase activity and existed predominantly in the GTP-bound form in transfected cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DIRAS Family, GTP Binding RAS Like 2 (DIRAS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DIRAS Family, GTP Binding RAS Like 2 (DIRAS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DIRAS Family, GTP Binding RAS Like 2 (DIRAS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DIRAS Family, GTP Binding RAS Like 2 (DIRAS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for DIRAS Family, GTP Binding RAS Like 2 (DIRAS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DIRAS Family, GTP Binding RAS Like 2 (DIRAS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DIRAS Family, GTP Binding RAS Like 2 (DIRAS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DIRAS Family, GTP Binding RAS Like 2 (DIRAS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DIRAS Family, GTP Binding RAS Like 2 (DIRAS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for DIRAS Family, GTP Binding RAS Like 2 (DIRAS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DIRAS Family, GTP Binding RAS Like 2 (DIRAS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DIRAS Family, GTP Binding RAS Like 2 (DIRAS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DIRAS Family, GTP Binding RAS Like 2 (DIRAS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DIRAS Family, GTP Binding RAS Like 2 (DIRAS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for DIRAS Family, GTP Binding RAS Like 2 (DIRAS2) ELISA Kit Customized Service Offer
  1. "Di-Ras, a distinct subgroup of ras family GTPases with unique biochemical properties."J. Biol. Chem. 277:41070-41078(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Crystal structure of DIRAS2."Submitted (DEC-2005) to the PDB data bank