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Mitochondrial Calcium Dependent Solute Carrier (MCSC)

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PCSCL; SLC25A25; APC3; MCSC3; SCAMC2; Small calcium-binding mitochondrial carrier protein 2; Ca(2+)-dependent solute carrier protein 3; Solute Carrier Family 25 Member 25

Mitochondrial Calcium Dependent Solute Carrier (MCSC)
CCC N630
HGNC 20663
MGI 1915913
PubMed 23935512
RGD 628666
UniProt Q6KCM7
Rat and human SLC25A25 share 97% identity. Northern blot analysis of several human tissues detected strongest expression in liver and skeletal muscle. SLC25A25 was also expressed in all segments of the human digestive tract examined. Immunofluorescence microscopy of a human liver carcinoma cell line detected endogenous MCSC in both punctate and filamentous patterns that overlapped mitochondria staining.
The deduced 568-amino acid protein shares 65% identity over 411 amino acids with SLC25A24. RT-PCR ELISA detected highest expression in fetal liver, followed by adult liver, skeletal muscle, ovary, hippocampus, and caudate nucleus. All other tissues and specific brain regions examined showed an intermediate level of SLC25A25 expression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitochondrial Calcium Dependent Solute Carrier (MCSC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitochondrial Calcium Dependent Solute Carrier (MCSC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitochondrial Calcium Dependent Solute Carrier (MCSC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitochondrial Calcium Dependent Solute Carrier (MCSC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitochondrial Calcium Dependent Solute Carrier (MCSC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitochondrial Calcium Dependent Solute Carrier (MCSC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitochondrial Calcium Dependent Solute Carrier (MCSC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitochondrial Calcium Dependent Solute Carrier (MCSC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitochondrial Calcium Dependent Solute Carrier (MCSC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitochondrial Calcium Dependent Solute Carrier (MCSC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitochondrial Calcium Dependent Solute Carrier (MCSC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitochondrial Calcium Dependent Solute Carrier (MCSC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitochondrial Calcium Dependent Solute Carrier (MCSC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitochondrial Calcium Dependent Solute Carrier (MCSC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitochondrial Calcium Dependent Solute Carrier (MCSC) ELISA Kit Customized Service Offer
  1. "Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains."J. Biol. Chem. 279:24701-24713(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution."J. Biol. Chem. 279:30722-30730(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]