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Polypeptide-N-Acetylgalactosaminyltransferase 12 (GALNT12)

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Polypeptide GalNAc transferase 12; Protein-UDP acetylgalactosaminyltransferase 12; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12

Polypeptide-N-Acetylgalactosaminyltransferase 12 (GALNT12)
CCC N600
HGNC 19877
MGI 2444664
PubMed 22461326
RGD 1562001
UniProt Q8IXK2
GALNT12 is a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases (EC 2.4.1.41), which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a hydroxyl amino acid on a polypeptide acceptor in the initial step of mucin-type O-linked protein glycosylation .
The deduced 581-amino acid protein contains an N-terminal cytoplasmic domain, transmembrane domain, and putative stem region. The predicted GALNT12 catalytic domain contains a GT1 motif, Gal/GalNAc transferase motif, and ricin-like lectin motif common to other GalNAcT family members. GALNT12 shares 32 to 56% amino acid sequence homology with other GalNAcT family members with highest homology to GALNT4.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polypeptide-N-Acetylgalactosaminyltransferase 12 (GALNT12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polypeptide-N-Acetylgalactosaminyltransferase 12 (GALNT12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polypeptide-N-Acetylgalactosaminyltransferase 12 (GALNT12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polypeptide-N-Acetylgalactosaminyltransferase 12 (GALNT12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polypeptide-N-Acetylgalactosaminyltransferase 12 (GALNT12) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polypeptide-N-Acetylgalactosaminyltransferase 12 (GALNT12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polypeptide-N-Acetylgalactosaminyltransferase 12 (GALNT12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polypeptide-N-Acetylgalactosaminyltransferase 12 (GALNT12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polypeptide-N-Acetylgalactosaminyltransferase 12 (GALNT12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polypeptide-N-Acetylgalactosaminyltransferase 12 (GALNT12) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polypeptide-N-Acetylgalactosaminyltransferase 12 (GALNT12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polypeptide-N-Acetylgalactosaminyltransferase 12 (GALNT12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polypeptide-N-Acetylgalactosaminyltransferase 12 (GALNT12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polypeptide-N-Acetylgalactosaminyltransferase 12 (GALNT12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polypeptide-N-Acetylgalactosaminyltransferase 12 (GALNT12) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12(1)."FEBS Lett. 524:211-218(2002) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers." Proc. Natl. Acad. Sci. U.S.A. 106:12921-12925(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Inherited deleterious variants in GALNT12 are associated with CRC susceptibility."Hum. Mutat. 33:1056-1058(2012) [PubMed] [Europe PMC] [Abstract]
  7. "GALNT12 is not a major contributor of familial colorectal cancer type X."Hum. Mutat. 35:50-52(2014) [PubMed] [Europe PMC] [Abstract]