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Solute Carrier Family 25, Member 22 (SLC25A22)

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GC1; NET44; Glutamate/H(+) symporter 1; Mitochondrial glutamate carrier 1

Solute Carrier Family 25, Member 22 (SLC25A22)
CCC N598
HGNC 19954
MGI 1915517
PubMed 19780765
RGD 1307826
UniProt Q9H936
The SLC25 gene family encodes mitochondrial carriers that transport a variety of metabolites across the inner mitochondrial membrane. SLC25A22, also known as GC1, is 1 of the 2 mitochondrial glutamate/H+ symporters, the other being SLC25A18.
The human SLC25A22 gene encodes a protein of 323 amino acids that is 95% identical to its mouse homolog and 63% identical to the protein sequence of SLC25A18. Purified SLC25A22 protein had an apparent molecular mass of 32.8 kD.The SLC25A22 protein catalyzes either the cotransport of L-glutamate with H+ or its exchange with OH-.SLC25A22 expression in areas of the brain proposed to contribute to the genesis and control of myoclonic seizures.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 25, Member 22 (SLC25A22) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 25, Member 22 (SLC25A22) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 25, Member 22 (SLC25A22) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 25, Member 22 (SLC25A22) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 25, Member 22 (SLC25A22) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 25, Member 22 (SLC25A22) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 25, Member 22 (SLC25A22) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 25, Member 22 (SLC25A22) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 25, Member 22 (SLC25A22) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 25, Member 22 (SLC25A22) ELISA Kit Customized Service Offer
  1. "Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms."J. Biol. Chem. 277:19289-19294(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "Impaired mitochondrial glutamate transport in autosomal recessive neonatal myoclonic epilepsy."Am. J. Hum. Genet. 76:334-339(2005) [PubMed] [Europe PMC] [Abstract]