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Talpid 3 (Talpid3)

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Talpid 3 (Talpid3)
CCC N597
HGNC 19960
MGI 1924217
PubMed 19144723
UniProt Q9BVV6
By sequencing clones obtained from a size-fractionated human brain cDNA library, Nagase et al. (1998) cloned KIAA0586. The deduced protein contains 1,533 amino acids. RT-PCR detected moderate expression in kidney only.Davey et al. (2006) identified KIAA0586 orthologs in vertebrates only. In chicken, the protein localized to the cytoplasm.
By radiation hybrid analysis, Nagase et al. (1998) mapped the KIAA0586 gene to chromosome 14.Talpid-3 is a chicken mutant with abnormal limb patterning and malformations in other regions of the embryo that depend on hedgehog (SHH) signaling. Davey et al. (2006) determined that talpid-3 is due to a frameshift mutation in the chicken ortholog of KIAA0586, leading to a truncated protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Talpid 3 (Talpid3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Talpid 3 (Talpid3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Talpid 3 (Talpid3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Talpid 3 (Talpid3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Talpid 3 (Talpid3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Talpid 3 (Talpid3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Talpid 3 (Talpid3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Talpid 3 (Talpid3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Talpid 3 (Talpid3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Talpid 3 (Talpid3) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Proteomic characterization of the human centrosome by protein correlation profiling."Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
  7. "The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation."Development 136:655-664(2009) [PubMed] [Europe PMC] [Abstract]