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Beclin-1-Associated Autophagy Related Key Regulator (Barkor)

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ATG14; ATG14L; Autophagy-related protein 14-like protein

Beclin-1-Associated Autophagy Related Key Regulator (Barkor)
CCC N596
HGNC 19962
MGI 1261775
RGD 1304610
UniProt Q6ZNE5
Mutation analysis revealed that both coiled-coil domains of Atg14 were required for the interaction of Atg14 with beclin-1 and Vps34. Gel filtration experiments revealed that endogenous Vps34, beclin-1, Atg14, and Rubicon coeluted in a complex of over 700 kD. However, immunoprecipitation analysis showed that Atg14 and Rubicon did not always coimmunoprecipitate in the same complex. Knockdown of Atg14 or beclin-1 via small interfering RNA impaired autophagy-mediated clearance of a test substrate. Knockdown of Atg14 in mouse fibroblasts resulted in accumulation of large puncta representing ubiquitinated protein inclusions and reduced the number of autophagosomes. Atg14 also stimulated Vps34 kinase activity, but only when coexpressed with beclin-1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beclin-1-Associated Autophagy Related Key Regulator (Barkor) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beclin-1-Associated Autophagy Related Key Regulator (Barkor) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beclin-1-Associated Autophagy Related Key Regulator (Barkor) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beclin-1-Associated Autophagy Related Key Regulator (Barkor) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beclin-1-Associated Autophagy Related Key Regulator (Barkor) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beclin-1-Associated Autophagy Related Key Regulator (Barkor) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beclin-1-Associated Autophagy Related Key Regulator (Barkor) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beclin-1-Associated Autophagy Related Key Regulator (Barkor) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beclin-1-Associated Autophagy Related Key Regulator (Barkor) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beclin-1-Associated Autophagy Related Key Regulator (Barkor) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beclin-1-Associated Autophagy Related Key Regulator (Barkor) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beclin-1-Associated Autophagy Related Key Regulator (Barkor) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beclin-1-Associated Autophagy Related Key Regulator (Barkor) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beclin-1-Associated Autophagy Related Key Regulator (Barkor) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beclin-1-Associated Autophagy Related Key Regulator (Barkor) ELISA Kit Customized Service Offer
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  10. "Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L."J. Cell Biol. 190:511-521(2010) [PubMed] [Europe PMC] [Abstract]
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  14. "ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes."Nature 0:0-0(2015) [PubMed] [Europe PMC] [Abstract]